COL4A3

Gene Symbol	COL4A3
Entrez Gene	1285
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	collagen, type IV, alpha 3 (Goodpasture antigen)
Other Description	collagen IV, alpha-3 polypeptide|collagen alpha-3(IV) chain|tumstatin
Swissprots	Q9UDJ9 Q01955 Q53RW8 Q9UDL0 Q9UDK9 Q9NYC4 Q53QQ1 Q53R14 Q9BQT2 Q9UDL1
Accessions	AAA52044 AAF63713 AAX93111 AAY14671 AAY24251 BAA25064 CAC36101 EAW70848 EAW70849 EAW70850 EAW70851 EAW70852 EAW70853 EAW70854 EAW70855 EAW70856 EAW70857 Q01955 AF258351 AAF72632 AU099354 BC156138 AAI56139 BM670570 BM712932 CD675393 EU268882 ABX71213 M81379 AAA51556 M92993 AAA21610 S55790 AAB19637 U02519 AAA18942 U02520 AAA18943 X80031 CAA56335 XM_005246276 XP_005246333 XM_005246277 XP_005246334 XM_005246280 XP_005246337 XM_006712245 XP_006712308 XM_011510555 XP_011508857 XM_011510556 XP_011508858 XR_241280 NM_000091 NP_000082 NM_031362 NM_031363 NM_031364 NM_031365 NM_031366
Function	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}.
Tissue Specificity	Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. According to PubMed:8083201, alpha 3 type IV collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial and perineurial nerves, fetal brain, fetal heart and fetal liver. According to PubMed:7523402, alpha 3 type IV collagen is strongly expressed in pancreas, neuroretina and calvaria and not expressed in adrenal, ileum and skin. Isoform 1 and isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle and spleen, in each of these tissues isoform 1 is more abundant than isoform 3.
Top Pathways	Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

COL4A (1042) - sc-52317 from Santa Cruz Biotechnology Prices $279.00 Sizes 500 µl ascites Host Mouse Clonality Monoclonal

COL4A (5F75) - sc-70866 from Santa Cruz Biotechnology Prices $279.00 Sizes 500 µl ascites Host Mouse Clonality Monoclonal

COL4A (COL-94) - sc-59814 from Santa Cruz Biotechnology Prices $279.00 Sizes 500 µl ascites Host Mouse Clonality Monoclonal

COL4A3 (N-16) - sc-18177 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

COL4A3 (T-15) - sc-18178 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-COL4A3 antibody - ab111742 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 antibody - ab73981 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-COL4A3 antibody - ab72643 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 antibody - ab85103 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody (aa801-850) - LS-C119456 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody (C-Terminus) - LS-C153397 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody (C-Terminus) - LS-C144856 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody - LS-C285479 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody (aa793-842) - LS-C135693 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody - LS-C342186 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody (aa1376-1425) - LS-C121068 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody (aa375-424) - LS-C135694 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody (aa1428-1670) - LS-C314904 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody (aa341-353) - LS-C204992 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-COL4A3 / Tumstatin Antibody (aa1407-1456) - LS-C121069 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Tumstatin/COL4A3 Antibody (762102) - MAB7546 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 762102

Tumstatin/COL4A3 Antibody - NBP1-85836 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Tumstatin Polyclonal Antibody - bs-2160R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Collagen IV α3 antibody produced in rabbit - SAB4500376 from Sigma-Aldrich Prices $325.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COL4A3 antibody produced in rabbit - HPA042064 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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