COL4A3

Gene Symbol	COL4A3
Entrez Gene	1285
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	collagen, type IV, alpha 3 (Goodpasture antigen)
Other Description	collagen IV, alpha-3 polypeptide|collagen alpha-3(IV) chain|tumstatin
Swissprots	Q9UDJ9 Q01955 Q53RW8 Q9UDL0 Q9UDK9 Q9NYC4 Q53QQ1 Q53R14 Q9BQT2 Q9UDL1
Accessions	AAA52044 AAF63713 AAX93111 AAY14671 AAY24251 BAA25064 CAC36101 EAW70848 EAW70849 EAW70850 EAW70851 EAW70852 EAW70853 EAW70854 EAW70855 EAW70856 EAW70857 Q01955 AF258351 AAF72632 AU099354 BC156138 AAI56139 BM670570 BM712932 CD675393 EU268882 ABX71213 M81379 AAA51556 M92993 AAA21610 S55790 AAB19637 U02519 AAA18942 U02520 AAA18943 X80031 CAA56335 XM_005246276 XP_005246333 XM_005246277 XP_005246334 XM_005246280 XP_005246337 XM_006712245 XP_006712308 XM_011510555 XP_011508857 XM_011510556 XP_011508858 XR_241280 NM_000091 NP_000082 NM_031362 NM_031363 NM_031364 NM_031365 NM_031366
Function	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}.
Tissue Specificity	Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. According to PubMed:8083201, alpha 3 type IV collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial and perineurial nerves, fetal brain, fetal heart and fetal liver. According to PubMed:7523402, alpha 3 type IV collagen is strongly expressed in pancreas, neuroretina and calvaria and not expressed in adrenal, ileum and skin. Isoform 1 and isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle and spleen, in each of these tissues isoform 1 is more abundant than isoform 3.
Top Pathways	Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human COL4A3 protein fragment - ab73664 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

COL4A3 / Tumstatin Antibody Blocking Peptide - LS-E21973 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COL4A3 Protein (OPPA01299) - OPPA01299 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Sf9 Insect Cells

Human Collagen IV protein - orb244124 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Collagen Type IV Alpha protein - orb81035 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source Sf9 insect cells

COL4A3 peptide - orb219039 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse

Tumstatin Blocking Peptide - abx062070 from Abbexa Category Peptide Species Human, Mouse

Collagen Type IV Alpha 3, Human Recombinant - 228-10263-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Sf9 insect cells. Species Human

Recombinant Human COL4A3 - 228-10263-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Sf9 insect cells. Species Human

Recombinant Human COL4A3 - 228-10263-3 from RayBiotech Category Protein Source Sf9 insect cells. Species Human

COL4A3 Human - PRPS-394 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Sf9 insect cells. Species Human

Recombinant Human Collagen Type IV Alpha 3 Protein - BP001905-PRO-387 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source Sf9 insect cells-derived. Species Human

Recombinant Human COL4A3, His-tagged - COL4A3-1369H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human COL4A3, His-tagged - COL4A3-27222TH from Creative Biomart Category Protein

Recombinant Human COL4A3 - COL4A3-179H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Collagen Type IV Alpha 3 Human - NKX-741 from Reagent Proteins Category Protein Prices $348.00, $5,334.00 Sizes 10.00 µg, 1 mg Source Sf9 insect cells Species Human

Recombinant Collagen Type IV Alpha 3 (COL4a3) - RPC143Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Tumstatin Blocking Peptide - CBP3176 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Recombinant Collagen Type IV Alpha 3 (COL4a3) - RPC143Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant human Collagen alpha-3(IV) chain - CSB-YP005743HU CSB-BP005743HU CSB-MP005743HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Collagen alpha-3(IV) chain - CSB-EP005743HU from Cusabio Category Protein Source E.coli Species Human

COL4A3, Peptide - MBS428488 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Bovine

Collagen Type IV Alpha 3 Human Recombinant - Pr20385 from ProMab Category Protein Prices $50.00, $130.00, $5,200.00 Sizes 2 μg, 10 μg, 1 mg Source Sf9 insect cells. Species Human

Tumstatin/COL4A3 Recombinant Protein Antigen - NBP1-85836PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

COL4A3-Blocking-Peptide-N-Term - BP21945a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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