| Gene Symbol | KCNJ12 |
|---|---|
| Entrez Gene | 3768 |
| Alt Symbol | IRK-2, IRK2, KCNJN1, Kir2.2, Kir2.2v, hIRK, hIRK1, hkir2.2x, kcnj12x |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, inwardly rectifying subfamily J, member 12 |
| Other Description | ATP-sensitive inward rectifier potassium channel 12|inward rectifier K(+) channel Kir2.2|inward rectifier K(+) channel Kir2.2v|inward rectifier K(+) channel Kir2.6|potassium channel, inwardly rectifying subfamily J member 12|potassium inwardly-rectifying channel, subfamily J, inhibitor 1|potassium inwardly-rectifying channel, subfamily J, member 12 |
| Swissprots | Q14500 Q15756 Q8NG63 O43401 |
| Accessions | AAC50615 BAC02718 BAD22701 EAW49109 Q14500 AB182123 BAD23901 AF005214 AAC01951 AK024229 BC027982 AAH27982 BM799671 DA115102 JF432412 ADZ15629 L36069 AAA65122 XM_005256625 XP_005256682 XM_011523831 XP_011522133 NM_021012 NP_066292 |
| Function | Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:12417321, ECO:0000269|PubMed:20921230, ECO:0000269|PubMed:7859381, ECO:0000269|PubMed:8647284}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Top Pathways | Oxytocin signaling pathway |
KIR2.2 CRISPR/Cas9 KO Plasmid (h) - sc-417554 from Santa Cruz Biotechnology
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KIR2.2 HDR Plasmid (h) - sc-417554-HDR from Santa Cruz Biotechnology
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KIR2.2 Double Nickase Plasmid (h) - sc-417554-NIC from Santa Cruz Biotechnology
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KIR2.2 Double Nickase Plasmid (h2) - sc-417554-NIC-2 from Santa Cruz Biotechnology
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KIR2.2 CRISPR Activation Plasmid (h) - sc-417554-ACT from Santa Cruz Biotechnology
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KIR2.2 CRISPR Activation Plasmid (h2) - sc-417554-ACT-2 from Santa Cruz Biotechnology
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KIR2.2 Lentiviral Activation Particles (h) - sc-417554-LAC from Santa Cruz Biotechnology
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KIR2.2 Lentiviral Activation Particles (h2) - sc-417554-LAC-2 from Santa Cruz Biotechnology
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KIR2.2 siRNA (h) - sc-93907 from Santa Cruz Biotechnology
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KIR2.2 shRNA Plasmid (h) - sc-93907-SH from Santa Cruz Biotechnology
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KIR2.2 shRNA (h) Lentiviral Particles - sc-93907-V from Santa Cruz Biotechnology
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Kir2.2 RNAi - H00003768-R01 from Novus Biologicals
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MISSION® esiRNA - EHU018761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2470 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2470 from Sigma-Aldrich
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KCNJ12 siRNA (Human) - CRH2544 from Cohesion Biosciences
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KCNJ12, siRNA - MBS8219734 from MyBioSource
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KCNJ12, siRNA - MBS8227580 from MyBioSource
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shRNA set against Human KCNJ12 (NM_021012.4) - SHH323215 from Creative biogene
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shRNA set against Human KCNJ12(NM_021012.4) - SHL189642 from Creative biogene
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KCNJ12 shRNA Plasmid (Human) - CHH2544 from Cohesion Biosciences
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KCNJ12 miRNA 3'UTR clone - MiUTR1H-05135 from Creative biogene
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