CENPI
| Gene Symbol | CENPI |
|---|---|
| Entrez Gene | 2491 |
| Alt Symbol | CENP-I, FSHPRH1, LRPR1, Mis6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | centromere protein I |
| Other Description | FSH primary response 1|FSH primary response protein 1|follicle-stimulating hormone primary response protein|interphase centromere complex protein 19|leucine-rich primary response protein 1 |
| Swissprots | Q96ED0 Q5JWZ9 Q92674 |
| Accessions | CAD34792 EAX02840 EAX02841 EAX02842 EAX02843 Q92674 AK302986 BAG64126 BC005967 BC012462 AAH12462 BG114761 BQ224168 M78295 X97249 CAA65884 XM_005262111 XP_005262168 XM_011530894 XP_011529196 XM_011530895 XP_011529197 XM_011530896 XP_011529198 XM_011530897 XP_011529199 XM_011530898 XP_011529200 XM_011530899 XP_011529201 XM_011530900 XP_011529202 XM_011530901 XP_011529203 XM_011530902 XP_011529204 NM_006733 NP_006724 |
| Function | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269|PubMed:12640463, ECO:0000269|PubMed:16622420}. |
| Subcellular Location | Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. |
CENP-I CRISPR/Cas9 KO Plasmid (h) - sc-405553 from Santa Cruz Biotechnology
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CENP-I HDR Plasmid (h) - sc-405553-HDR from Santa Cruz Biotechnology
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CENP-I Double Nickase Plasmid (h) - sc-405553-NIC from Santa Cruz Biotechnology
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CENP-I Double Nickase Plasmid (h2) - sc-405553-NIC-2 from Santa Cruz Biotechnology
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CENP-I CRISPR Activation Plasmid (h) - sc-405553-ACT from Santa Cruz Biotechnology
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CENP-I CRISPR Activation Plasmid (h2) - sc-405553-ACT-2 from Santa Cruz Biotechnology
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CENP-I Lentiviral Activation Particles (h) - sc-405553-LAC from Santa Cruz Biotechnology
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CENP-I Lentiviral Activation Particles (h2) - sc-405553-LAC-2 from Santa Cruz Biotechnology
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CENP-I siRNA (h) - sc-91123 from Santa Cruz Biotechnology
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CENP-I shRNA Plasmid (h) - sc-91123-SH from Santa Cruz Biotechnology
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CENP-I shRNA (h) Lentiviral Particles - sc-91123-V from Santa Cruz Biotechnology
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CENPI RNAi - H00002491-R01 from Novus Biologicals
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MISSION® esiRNA - EHU107611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5944 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5944 from Sigma-Aldrich
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CENPI siRNA (Human) - CRH1657 from Cohesion Biosciences
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CENPI - MBS8226304 from MyBioSource
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shRNA set against Human CENPI (NM_006733.2) - SHH261649 from Creative biogene
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shRNA set against Human CENPI(NM_006733.2) - SHG168055 from Creative biogene
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CENPI shRNA Plasmid (Human) - CHH1657 from Cohesion Biosciences
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CENPI miRNA 3'UTR clone - MiUTR1H-02040 from Creative biogene
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