| Gene Symbol | CHEK1 |
|---|---|
| Entrez Gene | 1111 |
| Alt Symbol | CHK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | checkpoint kinase 1 |
| Other Description | CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1|Chk1-S|cell cycle checkpoint kinase|checkpoint kinase-1|serine/threonine-protein kinase Chk1 |
| Swissprots | B5BTY6 B4DSK3 O14757 H2BI51 B4DDD0 A8K934 F5H7S4 |
| Accessions | AAM78553 AAQ76038 BAA84577 EAW67644 O14757 AA224205 AB451222 BAG70036 AB451345 BAG70159 AF016582 AAC51736 AF032874 AAB88852 AI750792 AK292549 BAF85238 AK293143 BAG56691 AK299783 BAG61665 AK300082 BAG61885 AW149126 BC004202 AAH04202 BC017575 AAH17575 BG191840 BG216281 BG218896 BG468734 BM455102 BP203333 BP207812 BX114781 BX419129 BX506561 CA441277 CA868104 DA567616 DQ892907 ABM83833 DQ896142 ABM87141 JF289264 AEB71796 XM_011542560 XP_011540862 XM_011542561 XP_011540863 XM_011542562 XP_011540864 XM_011542563 XP_011540865 NM_001114121 NP_001107593 NM_001114122 NP_001107594 NM_001244846 NP_001231775 NM_001274 NP_001265 NR_045204 NR_045205 |
| Function | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser- 124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of C |
| Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Nuclear export is mediated at least in part by XPO1/CRM1. Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B. |
| Tissue Specificity | Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon. {ECO:0000269|PubMed:9278511, ECO:0000269|PubMed:9382850}. |
| Top Pathways | Cell cycle, p53 signaling pathway, HTLV-I infection, Viral carcinogenesis |