CHEK1

Gene Symbol	CHEK1
Entrez Gene	1111
Alt Symbol	CHK1
Species	Human
Gene Type	protein-coding
Description	checkpoint kinase 1
Other Description	CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1|Chk1-S|cell cycle checkpoint kinase|checkpoint kinase-1|serine/threonine-protein kinase Chk1
Swissprots	B5BTY6 B4DSK3 O14757 H2BI51 B4DDD0 A8K934 F5H7S4
Accessions	AAM78553 AAQ76038 BAA84577 EAW67644 O14757 AA224205 AB451222 BAG70036 AB451345 BAG70159 AF016582 AAC51736 AF032874 AAB88852 AI750792 AK292549 BAF85238 AK293143 BAG56691 AK299783 BAG61665 AK300082 BAG61885 AW149126 BC004202 AAH04202 BC017575 AAH17575 BG191840 BG216281 BG218896 BG468734 BM455102 BP203333 BP207812 BX114781 BX419129 BX506561 CA441277 CA868104 DA567616 DQ892907 ABM83833 DQ896142 ABM87141 JF289264 AEB71796 XM_011542560 XP_011540862 XM_011542561 XP_011540863 XM_011542562 XP_011540864 XM_011542563 XP_011540865 NM_001114121 NP_001107593 NM_001114122 NP_001107594 NM_001244846 NP_001231775 NM_001274 NP_001265 NR_045204 NR_045205
Function	Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser- 124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of C
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Nuclear export is mediated at least in part by XPO1/CRM1. Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B.
Tissue Specificity	Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon. {ECO:0000269|PubMed:9278511, ECO:0000269|PubMed:9382850}.
Top Pathways	Cell cycle, p53 signaling pathway, HTLV-I infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Chk1 full length protein - ab69918 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Chk1 full length protein - ab60762 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Chk1 (phospho S317) peptide - ab94392 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Chk1 (phospho S345) peptide - ab93794 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Chk1 peptide - ab116584 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Chk1 peptide - ab116685 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Chk1 full length protein - ab158106 from Abcam Category Protein Source Wheat germ Species Human

Human Chk1 protein fragment - ab158107 from Abcam Category Protein Source Wheat germ Species Human

CHEK1 / CHK1 Antibody Blocking Peptide - LS-E25103 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHEK1 / CHK1 Antibody Blocking Peptide - LS-E11439 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHEK1 / CHK1 Antibody Blocking Peptide - LS-E11440 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHEK1 / CHK1 Antibody Blocking Peptide - LS-E7264 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHEK1 / CHK1 Antibody Blocking Peptide - LS-E7265 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHEK1 / CHK1 Antibody Blocking Peptide - LS-E6928 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Chk1 Protein - H00001111-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Chk1 Recombinant Protein - H00001111-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Chk1 Recombinant Protein - P4218 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Chk1 Recombinant Protein - P3852 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Chk1 Recombinant Protein - P4665 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Chk1 Peptide - P1301 from Novus Biologicals Category Peptide Species Human

Chk1 Peptide - P1300 from Novus Biologicals Category Peptide Species Human

Chk1 Peptide - P2488 from Novus Biologicals Category Peptide Species Human

CHK1-Antibody-S280-Blocking-Peptide - BP2184d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-CHK1S317-Antibody-Blocking-peptide - BP3070a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-CHK1S280-Antibody-Blocking-peptide - BP3069a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

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