| Gene Symbol | MIF |
|---|---|
| Entrez Gene | 4282 |
| Alt Symbol | GIF, GLIF, MMIF |
| Species | Human |
| Gene Type | protein-coding |
| Description | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
| Other Description | L-dopachrome isomerase|L-dopachrome tautomerase|macrophage migration inhibitory factor|phenylpyruvate tautomerase |
| Swissprots | Q6FHV0 B2R4S3 A5Z1R8 P14174 Q2V4Y5 |
| Accessions | AAA21814 ABB96245 EAW59620 P14174 AF469046 AAL78635 AK311929 BAG34870 BC000447 AAH00447 BC007376 BC007676 AAH07676 BC008914 AAH08914 BC013976 AAH13976 BC022414 AAH22414 BC051440 BC053376 AAH53376 BT007148 AAP35812 CR407644 CAG28572 CR456520 CAG30406 CR541651 CAG46452 CU013120 CAK54551 CU013408 CAK54850 DQ892195 ABM83121 DQ895390 ABM86316 JQ846015 AFM09726 L10612 AAA35892 M25639 AAA36315 M95775 AAA36179 Z23063 CAA80598 NM_002415 NP_002406 |
| Function | Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. {ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:17443469, ECO:0000269|PubMed:23776208}. |
| Subcellular Location | Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non- classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. |
| Top Pathways | Phenylalanine metabolism, Tyrosine metabolism |