RUNX1T1

Gene Symbol RUNX1T1
Entrez Gene 862
Alt Symbol AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
Species Human
Gene Type protein-coding
Description runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Other Description CBFA2T1 isoform r1t1-11a62|CBFA2T1 isoform r1t1-11a63|CBFA2T1 isoform r1t1-11a64|CBFA2T1 isoform r1t1-11a65|CBFA2T1 isoform r1t1-7a47|CBFA2T1 isoform r1t1-7a48|CBFA2T1 isoform r1t1-7a49|CBFA2T1 isoform r1t1-7a50|CBFA2T1 isoform r1t1-7a52|CBFA2T1 isoform r1t1-7d53|CBFA2T1 isoform r1t1-7d54|CBFA2T1 isoform r1t1-7d55|CBFA2T1 isoform r1t1-7d56|CBFA2T1 isoform r1t1-8a57|CBFA2T1 isoform r1t1-8a58|CBFA2T1 isoform r1t1-8a59|CBFA2T1 isoform r1t1-8a60|acute myelogenous leukemia 1 translocation 1, cyclin-D related|core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related|eight twenty one protein|myeloid translocation gene on 8q22|protein CBFA2T1|zinc finger MYND domain-containing protein 2
Swissprots Q7Z4J5 E7EPN4 Q6IBL1 O14784 Q14873 Q9BRZ0 Q6NXH1 Q06455 B7Z4P4 Q16239 Q06456
Accessions AAB32126 AAC28931 AAC28932 AAC28933 AAC28934 AAD14974 AAG33024 BAB88555 EAW91681 EAW91682 EAW91683 EAW91684 EAW91685 EAW91686 Q06455 AA506749 AF018283 AAC26143 AF131817 AK057707 AK297616 BAH12630 AK312592 BAG35486 AL049240 BC005850 AAH05850 BC067078 AAH67078 BC139783 BT009871 AAP88873 CR456792 CAG33073 D14289 BAA03247 D14821 BAA03558 D43638 BAA07755 DA499596 DA500281 DA503204 DA504975 DA770917 DA774453 DA776825 DA776968 DA777240 DA779230 DA787376 DA795825 DA796892 JF432279 ADZ15496 KF946505 AHK05721 KF946506 AHK05722 KF946507 AHK05723 KF946508 AHK05724 KF946509 AHK05725 KF946510 AHK05726 KF946511 AHK05727 KF946512 AHK05728 KF946513 AHK05729 KF946514 AHK05730 KF946515 AHK05731 KF946516 AHK05732 KF946517 AHK05733 KF946518 AHK05734 KF946519 AHK05735 KF946520 AHK05736 KF946521 AHK05737 KF946522 AHK05738 KF946523 AHK05739 S82690 AAB46751 X79990 CAA56311 Z35296 XM_006716676 XP_006716739 XM_011517351 XP_011515653 XM_011517352 XP_011515654 XM_011517353 XP_011515655 XR_928359 NM_001198625 NP_001185554 NM_001198626 NP_001185555 NM_001198627 NP_001185556 NM_001198628 NP_001185557 NM_001198629 NP_001185558 NM_001198630 NP_001185559 NM_001198631 NP_001185560 NM_001198632 NP_001185561 NM_001198633 NP_001185562 NM_001198634 NP_001185563 NM_001198679 NP_001185608 NM_004349 NP_004340 NM_175634 NP_783552 NM_175635 NP_783553 NM_175636 NP_783554
Function Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12. {ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00440, ECO:0000269|PubMed:10973986}. Note=Colocalizes with ATN1 in discrete nuclear dots.
Tissue Specificity Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
Top Pathways Acute myeloid leukemia, Transcriptional misregulation in cancer

ETO Antibody - 4498 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blotting analysis of extracts of MOLT4 and K562 cells using ETO Antibody.

ETO (C-20) - sc-9737 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ETO (C-20): sc-9737. Western blot analysis of ETO expression in AML-193 (A), CCRF-CEM (B), CCRF-HSB-2 (C), HL-60 (D), HuT 78 (E) and MOLT-4 (F) whole cell lysates.

ETO (H-54) - sc-28693 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ETO (S-19) - sc-9736 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ETO (S-19): sc-9736. Western blot analysis of ETO expression in AML-193 (A), CCRF-CEM (B), CCRF-HSB-2 (C), HL-60 (D), HuT 78 (E) and MOLT-4 (F) whole cell lysates.

ETO (3H11) - sc-134335 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ETO (3H11): sc-134335. Western blot analysis of ETO expression in human ETO transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-RUNX1T1 / ETO antibody - ab200392 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling RUNX1T1 / ETO with ab200392 at 1/35 dilution.

Anti-RUNX1T1 / ETO antibody - ab124269 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RUNX1T1 / ETO antibody (ab124269) at 0.4 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : Jurkat whole cell lysate at 50 µgLane 4 : HeLa whole cell lysate at 50 µgdeveloped using the ECL techniqueExposure time : 30 seconds

Anti-RUNX1T1 / ETO antibody - ab26161 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RUNX1T1 / ETO antibody (ab26161) at 1.25 µg/ml + HepG2 cell lysateSecondaryHRP conjugated anti-Rabbit IgG diluted 1/50000 - 100000

Anti-RUNX1T1 / ETO antibody [1H1] - ab128084 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H1
Overlay histogram showing K562 cells stained with ab128084 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab128084, 1/50 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in K562 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-RUNX1T1 / ETO antibody - C-terminal - ab187335 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-RUNX1T1 / ETO antibody - C-terminal (ab187335) at 1/1000 dilutionLane 1 : Mouse brain extractLane 2 : Mouse thymus extract

Anti-RUNX1T1 / ETO antibody - N-terminal - ab187337 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RUNX1T1 / ETO antibody - N-terminal (ab187337) at 1/1000 dilutionLane 1 : Mouse brain total cell extractsLane 2 : Mouse thymus total cell extracts

Anti-RUNX1T1 / ETO Antibody (clone 1H1) - LS-C337730 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H1
Anti-RUNX1T1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RUNX1T1.

Anti-RUNX1T1 / ETO Antibody (aa275-291) - LS-C16617 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RUNX1T1 / ETO Antibody (aa221-270) - LS-C31287 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-RUNX1T1 / ETO Antibody (N-Terminus) - LS-C347705 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-RUNX1T1 / ETO Antibody (aa288-337) - LS-C112160 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RUNX1T1 antibody LS-C112160 Western blot of 293T cell lysate.

Anti-RUNX1T1 / ETO Antibody (N-Terminus) - LS-C146291 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RUNX1T1 antibody LS-C146291 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-RUNX1T1 / ETO Antibody (aa554-604) - LS-C290179 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ETO by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from 293T (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), Jurkat (J; 50 ug) and HeLa (H; 50 ug) cells. Antibodies: Affinity purified rabbit anti-ETO antibody used for WB at 0.4 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. ETO was also immunoprecipitated by rabbit anti-ETO antibody BL12518, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A and B).

Anti-RUNX1T1 / ETO Antibody - LS-C335083 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Mouse brain , using RUNX1T1 antibody.

Anti-RUNX1T1 / ETO Antibody (clone 5A12) - LS-C196824 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5A12
Immunofluorescence of monoclonal antibody to RUNX1T1 on HeLa cell . [antibody concentration 10 ug/ml]

RUNX1T1/ETO Antibody (5A12) - H00000862-M01 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5A12
Western Blot: RUNX1T1/ETO Antibody (5A12) [H00000862-M01] - Analysis of RUNX1T1 expression in transfected 293T cell line by RUNX1T1 monoclonal antibody (M01), clone 5A12. Lane 1: RUNX1T1 transfected lysate (67.566 KDa). Lane 2: Non-transfected lysate.

RUNX1T1/ETO Antibody (1H1) - NBP2-02023 from Novus Biologicals

Prices $529.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H1
Western Blot: RUNX1T1/ETO Antibody (1H1) [NBP2-02023] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RUNX1T1/ETO (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RUNX1T1/ETO.

RUNX1T1/ETO Antibody - 37450002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: RUNX1T1/ETO Antibody [37450002]

RUNX1T1/ETO Antibody - H00000862-B02 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: RUNX1T1/ETO Antibody [H00000862-B02] - analysis of RUNX1T1 expression in transfected 293T cell line by RUNX1T1 MaxPab polyclonal antibody (B02). Lane 1: RUNX1T1 transfected lysate (64.40 KDa). Lane 2: Non-transfected lysate.

RUNX1T1/ETO Antibody - H00000862-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RUNX1T1/ETO Antibody [H00000862-D01P] - Analysis of RUNX1T1 expression in transfected 293T cell line by RUNX1T1 polyclonal antibody.Lane 1: RUNX1T1 transfected lysate(64.40 KDa).Lane 2: Non-transfected lysate.
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