Gene Symbol | TMBIM4 |
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Entrez Gene | 51643 |
Alt Symbol | CGI-119, GAAP, LFG4, S1R, ZPRO |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane BAX inhibitor motif containing 4 |
Other Description | Golgi anti-apoptotic protein|Z-protein|protein lifeguard 4|transmembrane BAX inhibitor motif-containing protein 4 |
Swissprots | Q9HC24 Q9Y3C2 Q9UHY5 Q542Z6 |
Accessions | CAF86277 EAW97158 EAW97159 EAW97160 EAW97161 EAW97162 Q9HC24 AF113127 AAF14868 AF151877 AAD34114 AF161526 AAF29141 AF182041 AAG16898 AF182414 AAG14950 AK075069 BAC11384 AK127285 AK225158 AL117550 BC004401 AAH04401 BC020613 BC052273 BC070366 BC094852 BC148528 AAI48529 BC156584 AAI56585 BG534013 BM989676 DC361259 NM_001282606 NP_001269535 NM_001282609 NP_001269538 NM_001282610 NP_001269539 NM_016056 NP_057140 |
Function | Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release. {ECO:0000269|PubMed:17319741, ECO:0000269|PubMed:19553469}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:17319741, ECO:0000269|PubMed:22418439}; Multi- pass membrane protein {ECO:0000269|PubMed:17319741, ECO:0000269|PubMed:22418439}. |
GAAP CRISPR/Cas9 KO Plasmid (h) - sc-409949 from Santa Cruz Biotechnology
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GAAP HDR Plasmid (h) - sc-409949-HDR from Santa Cruz Biotechnology
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GAAP Double Nickase Plasmid (h) - sc-409949-NIC from Santa Cruz Biotechnology
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GAAP Double Nickase Plasmid (h2) - sc-409949-NIC-2 from Santa Cruz Biotechnology
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GAAP CRISPR Activation Plasmid (h) - sc-409949-ACT from Santa Cruz Biotechnology
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GAAP CRISPR Activation Plasmid (h2) - sc-409949-ACT-2 from Santa Cruz Biotechnology
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GAAP Lentiviral Activation Particles (h) - sc-409949-LAC from Santa Cruz Biotechnology
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GAAP Lentiviral Activation Particles (h2) - sc-409949-LAC-2 from Santa Cruz Biotechnology
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GAAP siRNA (h) - sc-96014 from Santa Cruz Biotechnology
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GAAP shRNA Plasmid (h) - sc-96014-SH from Santa Cruz Biotechnology
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GAAP shRNA (h) Lentiviral Particles - sc-96014-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU087071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21430 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21430 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07569 from Sigma-Aldrich
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TMBIM4 siRNA (Human) - CRH9875 from Cohesion Biosciences
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TMBIM4 - MBS8217603 from MyBioSource
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shRNA set against Human TMBIM4(NM_016056.2) - SHL074316 from Creative biogene
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TMBIM4 shRNA Plasmid (Human) - CHH9875 from Cohesion Biosciences
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TMBIM4 miRNA 3'UTR clone - MiUTR1H-10453 from Creative biogene
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