| Gene Symbol | St3gal1 |
|---|---|
| Entrez Gene | 20442 |
| Alt Symbol | 5330418N22Rik, AI467004, ST3GalI, Siat4, Siat4a, St3gal-1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
| Other Description | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1|CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase|Gal beta1,3 GalNAc alpha2,3 sialyltransferase|SIAT4-A|ST3GAL-I sialyltransferase|ST3Gal I|ST3GalA.1|ST3O|alpha 2,3-ST 1|beta-galactoside alpha-2,3-sialyltransferase 1|gal-NAc6S|gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase|sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)|sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase) |
| Swissprots | Q11202 P54751 |
| Accessions | EDL29390 P54751 AK030491 AK031344 BAC27356 AK078469 BAC37290 AK086286 AK137093 AK138747 BAE23767 AK143207 BAE25305 AK169958 BAE41481 AK171719 BC023130 BC038885 BC040763 BC084730 AAH84730 BC099670 AAH99670 BC099693 AAH99693 X73523 CAA51919 XM_006520664 XP_006520727 XM_006520665 XP_006520728 XM_011245528 XP_011243830 XM_011245529 XP_011243831 NM_001033487 NM_009177 NP_033203 |
| Function | It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. |
| Tissue Specificity | Highly expressed in submaxillary gland and to a much lesser extent in liver, lung, kidney, heart and brain. |
| Top Pathways | Mucin type O-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - ganglio series |