| Gene Symbol | St3gal1 |
|---|---|
| Entrez Gene | 20442 |
| Alt Symbol | 5330418N22Rik, AI467004, ST3GalI, Siat4, Siat4a, St3gal-1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
| Other Description | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1|CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase|Gal beta1,3 GalNAc alpha2,3 sialyltransferase|SIAT4-A|ST3GAL-I sialyltransferase|ST3Gal I|ST3GalA.1|ST3O|alpha 2,3-ST 1|beta-galactoside alpha-2,3-sialyltransferase 1|gal-NAc6S|gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase|sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)|sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase) |
| Swissprots | Q11202 P54751 |
| Accessions | EDL29390 P54751 AK030491 AK031344 BAC27356 AK078469 BAC37290 AK086286 AK137093 AK138747 BAE23767 AK143207 BAE25305 AK169958 BAE41481 AK171719 BC023130 BC038885 BC040763 BC084730 AAH84730 BC099670 AAH99670 BC099693 AAH99693 X73523 CAA51919 XM_006520664 XP_006520727 XM_006520665 XP_006520728 XM_011245528 XP_011243830 XM_011245529 XP_011243831 NM_001033487 NM_009177 NP_033203 |
| Function | It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. |
| Tissue Specificity | Highly expressed in submaxillary gland and to a much lesser extent in liver, lung, kidney, heart and brain. |
| Top Pathways | Mucin type O-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - ganglio series |
St3Gal-I CRISPR/Cas9 KO Plasmid (m) - sc-422935 from Santa Cruz Biotechnology
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St3Gal-I HDR Plasmid (m) - sc-422935-HDR from Santa Cruz Biotechnology
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St3Gal-I Double Nickase Plasmid (m) - sc-422935-NIC from Santa Cruz Biotechnology
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St3Gal-I Double Nickase Plasmid (m2) - sc-422935-NIC-2 from Santa Cruz Biotechnology
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St3Gal-I CRISPR Activation Plasmid (m) - sc-422935-ACT from Santa Cruz Biotechnology
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St3Gal-I CRISPR Activation Plasmid (m2) - sc-422935-ACT-2 from Santa Cruz Biotechnology
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St3Gal-I Lentiviral Activation Particles (m) - sc-422935-LAC from Santa Cruz Biotechnology
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St3Gal-I Lentiviral Activation Particles (m2) - sc-422935-LAC-2 from Santa Cruz Biotechnology
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St3Gal-I siRNA (m) - sc-153859 from Santa Cruz Biotechnology
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St3Gal-I shRNA Plasmid (m) - sc-153859-SH from Santa Cruz Biotechnology
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St3Gal-I shRNA (m) Lentiviral Particles - sc-153859-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU039421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42116 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42116 from Sigma-Aldrich
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ST3GAL1 siRNA (Mouse) - CRM3717 from Cohesion Biosciences
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ST3GAL1 - MBS8231518 from MyBioSource
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shRNA set against Mouse ST3 (NM_009177.4) - SHH418792 from Creative biogene
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shRNA set against Mouse St3gal1(NM_009177.4) - SHL037938 from Creative biogene
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Mouse ST3GAL1 siRNA - orb283193 from Biorbyt
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ST3GAL1 shRNA Plasmid (Mouse) - CHM3717 from Cohesion Biosciences
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ST3GAL1 miRNA 3'UTR clone - MiUTR1M-11271 from Creative biogene
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