| Gene Symbol |
TSEN15
|
| Entrez Gene |
116461
|
| Alt Symbol |
C1orf19, sen15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TSEN15 tRNA splicing endonuclease subunit
|
| Other Description |
tRNA splicing endonuclease 15 homolog|tRNA-intron endonuclease Sen15|tRNA-splicing endonuclease subunit Sen15
|
| Swissprots |
Q9BZQ5 B4DKP0 Q8WW01
|
| Accessions |
EAW91173 EAW91174 EAW91175 Q8WW01 AF288394 AAG60614 AK098196 BAG53590 AK296655 BAG59252 AK307241 BC022030 AAH22030 BG285158 BI821111 BM146150 BM789892 BM887891 BP326115 BU195337 CB158796 HQ448688 ADQ33166 XM_006711148 XP_006711211 XM_011509139 XP_011507441 NM_001127394 NP_001120866 NM_001300764 NP_001287693 NM_001300766 NP_001287695 NM_052965 NP_443197 NR_023349 NR_125335
|
| Function |
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.
|
| Subcellular Location |
Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in testis and uterus. {ECO:0000269|PubMed:11318611}.
|
![Western Blot: sen15 Overexpression Lysate (Adult Normal) [NBL1-17354] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for sen15.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8370_sen15%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17354-img0002.jpg)