| Gene Symbol | STMN1 |
|---|---|
| Entrez Gene | 3925 |
| Alt Symbol | C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN |
| Species | Human |
| Gene Type | protein-coding |
| Description | stathmin 1 |
| Other Description | leukemia-associated phosphoprotein p18|metablastin|oncoprotein 18|phosphoprotein 19|phosphoprotein p19|prosolin|stathmin|stathmin 1/oncoprotein 18|transmembrane protein C1orf215 |
| Swissprots | B7Z8N4 P16949 D3DPJ5 B2R4E7 A2A2D1 |
| Accessions | AAA59971 CAA64398 EAX07854 EAX07855 EAX07856 EAX07857 EAX07858 EAX07859 EAX07860 EAX07861 P16949 AB209282 BAD92519 AB451319 BAG70133 AB451448 BAG70262 AK054594 AK056768 BAB71277 AK303692 BAH14020 AK311801 BAG34744 AM392854 CAL37732 AV714035 BC014353 AAH14353 BC023313 BC028398 BC082228 AAH82228 BC114443 AAI14444 BC114502 AAI14503 BF686314 BG030679 BG493669 BM563894 BQ428400 BQ772197 BX647885 D28428 BAA05794 J04991 AAA59980 X53305 CAA37391 Z11566 CAA77660 NM_001145454 NP_001138926 NM_005563 NP_005554 NM_203399 NP_981944 NM_203401 NP_981946 NM_152497 |
| Function | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytoskeleton. |
| Tissue Specificity | Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. {ECO:0000269|PubMed:12676564, ECO:0000269|PubMed:1917919}. |
| Top Pathways | MAPK signaling pathway, MicroRNAs in cancer |