STMN1

Gene Symbol STMN1
Entrez Gene 3925
Alt Symbol C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN
Species Human
Gene Type protein-coding
Description stathmin 1
Other Description leukemia-associated phosphoprotein p18|metablastin|oncoprotein 18|phosphoprotein 19|phosphoprotein p19|prosolin|stathmin|stathmin 1/oncoprotein 18|transmembrane protein C1orf215
Swissprots B7Z8N4 P16949 D3DPJ5 B2R4E7 A2A2D1
Accessions AAA59971 CAA64398 EAX07854 EAX07855 EAX07856 EAX07857 EAX07858 EAX07859 EAX07860 EAX07861 P16949 AB209282 BAD92519 AB451319 BAG70133 AB451448 BAG70262 AK054594 AK056768 BAB71277 AK303692 BAH14020 AK311801 BAG34744 AM392854 CAL37732 AV714035 BC014353 AAH14353 BC023313 BC028398 BC082228 AAH82228 BC114443 AAI14444 BC114502 AAI14503 BF686314 BG030679 BG493669 BM563894 BQ428400 BQ772197 BX647885 D28428 BAA05794 J04991 AAA59980 X53305 CAA37391 Z11566 CAA77660 NM_001145454 NP_001138926 NM_005563 NP_005554 NM_203399 NP_981944 NM_203401 NP_981946 NM_152497
Function Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytoskeleton.
Tissue Specificity Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. {ECO:0000269|PubMed:12676564, ECO:0000269|PubMed:1917919}.
Top Pathways MAPK signaling pathway, MicroRNAs in cancer

Phospho-Stathmin (Ser38) (D19H10) Rabbit mAb - 4191 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D19H10
Western blot analysis of extracts from HT-29 cells, untreated or treated with nocodazole alone (100 ng/mL 24 hours) or nocodazole followed by λ and calf intestinal phosphatases, using Phospho-Stathmin (Ser38) (D19H10) Rabbit mAb.

Phospho-Stathmin (Ser38) Antibody - 3426 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT-29 cells, untreated or treated with nocodazole for 16 hours at 100 ng/mL and unblocked (left), blocked with phospho-stathmin (Ser38) peptide (middle) or phospho-stathmin (Ser16) peptide (right), using Phospho-Stathmin (Ser38) Antibody.

Phospho-Stathmin (Ser16) Antibody - 3353 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and C2C12 cells, untreated or nocodazole-treated, using Phospho-Stathmin (Ser16) Antibody.

Stathmin Antibody - 3352 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C6, SH-SY5Y, SK-N-MC, PC12, COS and HeLa cells, using Stathmin Antibody.

Op18 (A-4) - sc-48362 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Op18 (A-4): sc-48362. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing cytoplasmic staining of follicle and non-follicle cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Op18 (FL-149) - sc-20796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Op18 (FL-149): sc-20796. Western blot analysis of Op18 expression in SK-MEL-28 whole cell lysate.

Op18 (N-20) - sc-10899 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Op18 (N-20): sc-10899. Immunofluorescence staining of methanol-fixed Jurkat cells showing cytoplasmic localization.

Op18 (E-3) - sc-55531 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Op18 (E-3): sc-55531. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Op18 (13) - sc-130333 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Op18 (13): sc-130333. Western blot analysis of human recombinant Op18.

Op18 (L-15) - sc-10897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Op18 (L-15): sc-10897. Western blot analysis of Op18 expression in PC-12 whole cell lysate.

Op18 (53) - sc-136010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Op18 (53): sc-136010. Western blot analysis of Op18 expression in Jurkat whole cell lysate.

p-Op18 (Ser 16)-R - sc-12948-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
p-Op18 (Ser 16)-R: sc-12948-R. Western blot detection of Op18 phosphorylation in Jurkat cells. Antibody was preincubated with cognate non-phosphorylated (A) or phosphorylated peptide (B).

p-Op18 (Ser 25) - sc-101809 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Op18 (Ser 38): sc-101809. Western blot analysis of phosphorylated Op18 expression in untreated (A) and PMA-treated (B) Jurkat whole cell lysates.

p-Op18 (Ser 63) - sc-12949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-Op18 (Ser 38) - sc-101810 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Op18 (Ser 38): sc-101810. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining.

Anti-Stathmin 1 (phospho S16) antibody - ab47328 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab47328 staining human breast carcinoma tissue by IHC-P (left hand panel). The right hand panel shows staining in the presence of phospho-peptide.

Anti-Stathmin 1 (phospho S24) antibody - ab47398 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Stathmin 1 (phospho S24) antibody (ab47398) at 1/500 dilutionLane 1 : Extracts from Jurkat cells treated with PMA Lane 2 : Extracts from Jurkat cells untreated

Anti-Stathmin 1 (phospho S24) antibody - ab195780 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Stathmin 1 (phospho S24) antibody (ab195780) at 1/500 dilutionLane 1 : PMA treated Jurkat whole cell lysate with antigen-specific peptideLane 2 : PMA treated Jurkat whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-Stathmin 1 (phospho S24) antibody [EP2124Y] - ab62336 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2124Y
All lanes : Anti-Stathmin 1 (phospho S24) antibody [EP2124Y] (ab62336) at 1/1000 dilutionLane 1 : HeLa cell lysate (untreated)Lane 2 : HeLa cell lysate (treated with FBS+Calyculin A)Lysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP conjugate at 1/2000 dilution

Anti-Stathmin 1 (phospho S25) antibody - ab194752 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Stathmin 1 (phospho S25) antibody (ab194752) at 1/500 dilutionLane 1 : Jurkat cell extract, untreatedLane 2 : Jurkat cell extract, treated with PMA

Anti-Stathmin 1 (phospho S37) antibody - ab47399 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Stathmin 1 (phospho S37) antibody (ab47399) at 1/500 dilutionLane 1 : Extracts from Jurkat cells treated with PMA (1ng/ml, 15min) Lane 2 : Extracts from Jurkat cells untreated

Anti-Stathmin 1 (phospho S38) antibody - ab194757 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue labeling Stathmin 1 (phospho S38) with ab194757 at 1/50 dilution.

Anti-Stathmin 1 (phospho S62) antibody - ab192648 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Stathmin 1 (phospho S62) antibody (ab192648) at 1/500 dilutionLane 1 : COS cell extract treated with nocodazoleLane 2 : COS cell extract treated with nocodazole with antigen-specific peptide

Anti-Stathmin 1 (phospho S63) antibody [EPR1574] - ab76583 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1574
ab76583, at a 1/250 dilution, staining Stathmin 1 in paraffin embedded human brain tissue by Immunohistochemistry.

Anti-Stathmin 1 antibody - ab52906 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Stathmin 1 was immunoprecipitated using 0.5mg PC12 whole cell extract, 5µg of Rabbit polyclonal to Stathmin 1 and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, PC12 whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab52906.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 17kDa; Stathmin 1
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