TLR8

Gene Symbol TLR8
Entrez Gene 51311
Alt Symbol CD288
Species Human
Gene Type protein-coding
Description toll-like receptor 8
Other Description -
Swissprots D1CS76 B3Y654 D1CS70 Q9NR97 Q6UXL6 Q9NYG9 Q495P4
Accessions AAZ95433 AAZ95434 AAZ95435 AAZ95436 AAZ95437 AAZ95438 AAZ95439 AAZ95440 AAZ95441 EAW98808 EAW98809 Q9NR97 AB445666 BAG55063 AF245703 AAF78036 AF246971 AAF64061 AK075117 BAC11412 AK297024 BAG59554 AK307562 AK314240 AY358296 AAQ88663 BC101074 AAI01075 BC101075 AAI01076 BC101076 AAI01077 BC101077 AAI01078 XM_011545529 XP_011543831 XM_011545530 XP_011543832 NM_016610 NP_057694 NM_138636 NP_619542
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:23520111}.
Subcellular Location Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
Top Pathways Toll-like receptor signaling pathway

TLR8 CRISPR/Cas9 KO Plasmid (h) - sc-401721 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR8 HDR Plasmid (h) - sc-401721-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR8 Double Nickase Plasmid (h) - sc-401721-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR8 Double Nickase Plasmid (h2) - sc-401721-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR8 CRISPR Activation Plasmid (h) - sc-401721-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR8 CRISPR Activation Plasmid (h2) - sc-401721-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR8 Lentiviral Activation Particles (h) - sc-401721-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR8 Lentiviral Activation Particles (h2) - sc-401721-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLR8 siRNA (h) - sc-40268 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLR8 shRNA Plasmid (h) - sc-40268-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLR8 shRNA (h) Lentiviral Particles - sc-40268-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLR8 RNAi - H00051311-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TLR8 RNAi - H00051311-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU093811 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21405 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21405 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TLR8 siRNA (Human) - CRH9688 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TLR8 - MBS827492 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TLR8 (NM_138636.4) - SHH428032 from Creative biogene

Category siRNA
Species Reactivities Human

TLR8 shRNA Plasmid (Human) - CHH9688 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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