Gene Symbol | MPO |
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Entrez Gene | 4353 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | myeloperoxidase |
Other Description | - |
Swissprots | A1L4B8 Q9UCL7 Q4PJH5 P05164 Q14862 |
Accessions | AAA59864 AAA59865 AAA60346 AAY68218 BAA03362 CAA00809 CAA33438 CAA45918 CAA85783 CAS01769 CAS01770 EAW94470 EAW94471 EAW94472 EAW94473 P05164 BC130476 AAI30477 HQ258645 ADR83396 J02694 AAA59896 M19507 AAA59863 S56200 AAB25582 X04876 CAA28564 XM_011524821 XP_011523123 XM_011524822 XP_011523124 XM_011524823 XP_011523125 NM_000250 NP_000241 |
Function | Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. |
Subcellular Location | Lysosome. |
Top Pathways | Phagosome, Transcriptional misregulation in cancer |
MPO CRISPR/Cas9 KO Plasmid (h) - sc-400822 from Santa Cruz Biotechnology
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MPO HDR Plasmid (h) - sc-400822-HDR from Santa Cruz Biotechnology
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MPO Double Nickase Plasmid (h) - sc-400822-NIC from Santa Cruz Biotechnology
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MPO Double Nickase Plasmid (h2) - sc-400822-NIC-2 from Santa Cruz Biotechnology
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MPO CRISPR Activation Plasmid (h) - sc-400822-ACT from Santa Cruz Biotechnology
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MPO CRISPR Activation Plasmid (h2) - sc-400822-ACT-2 from Santa Cruz Biotechnology
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MPO Lentiviral Activation Particles (h) - sc-400822-LAC from Santa Cruz Biotechnology
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MPO Lentiviral Activation Particles (h2) - sc-400822-LAC-2 from Santa Cruz Biotechnology
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MPO siRNA (h) - sc-43941 from Santa Cruz Biotechnology
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MPO shRNA Plasmid (h) - sc-43941-SH from Santa Cruz Biotechnology
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MPO shRNA (h) Lentiviral Particles - sc-43941-V from Santa Cruz Biotechnology
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Myeloperoxidase/MPO RNAi - H00004353-R01 from Novus Biologicals
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MISSION® esiRNA - EHU069241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1100 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1100 from Sigma-Aldrich
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MPO siRNA (Human) - CRH2956 from Cohesion Biosciences
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shRNA set against Human Mpo (NM_000250.1) - SHH343912 from Creative biogene
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MPO shRNA Plasmid (Human) - CHH2956 from Cohesion Biosciences
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MPO miRNA 3'UTR clone - MiUTR1H-06398 from Creative biogene
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