CTCFL

Gene Symbol CTCFL
Entrez Gene 140690
Alt Symbol BORIS, CT27, CTCF-T, HMGB1L1, dJ579F20.2
Species Human
Gene Type protein-coding
Description CCCTC-binding factor (zinc finger protein)-like
Other Description BORIS-like protein|CTCF paralog|CTCF-like protein|HMG-1L1|brother of the regulator of imprinted sites|cancer/testis antigen 27|putative high mobility group protein 1-like 1|putative high mobility group protein B1-like 1|transcriptional repressor CTCFL|zinc finger protein CTCF-T
Swissprots E9PBA9 A6XGM2 A0S6W1 A6XGL8 Q8NI51 A6XGN1 A6XGM8 A6XGN3 A1L4C6 Q9BZ30 A6XGN2 Q9NQJ3 A6XGM3 E7EUE3 A6XGN4 E7EQ27 A6XGN0 Q5JUG4
Accessions EAW75516 EAW75517 EAW75518 Q8NI51 AF336042 AAM28645 AK128070 BAG54626 AK313990 BAG36702 AW243377 AY071919 AAL61541 BC060763 BC130486 AAI30487 BC137482 AAI37483 BC137483 AAI37484 DQ294738 ABB92839 DQ778108 ABH10090 DQ778109 ABH10091 DQ778110 ABH10092 DQ778111 ABH10093 DQ778112 ABH10094 DQ778113 ABH10095 DQ778114 ABH10096 DQ778115 ABH10097 DQ778116 ABH10098 DQ778117 ABH10099 DQ778118 ABH10100 DQ778119 ABH10101 DQ778120 ABH10102 DQ778121 ABH10103 DQ778122 ABH10104 DQ778123 ABH10105 DQ778124 ABH10106 DQ778125 ABH10107 DQ778126 ABH10108 DQ778127 ABH10109 DQ778128 ABH10110 DQ778129 ABH10111 DQ778130 ABH10112 DQ778131 ABH10113 NM_001269040 NP_001255969 NM_001269041 NP_001255970 NM_001269042 NP_001255971 NM_001269043 NP_001255972 NM_001269044 NP_001255973 NM_001269045 NP_001255974 NM_001269046 NP_001255975 NM_001269047 NP_001255976 NM_001269048 NP_001255977 NM_001269049 NP_001255978 NM_001269050 NP_001255979 NM_001269051 NP_001255980 NM_001269052 NP_001255981 NM_001269054 NP_001255983 NM_001269055 NP_001255984 NM_080618 NP_542185 NR_072975
Function Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. {ECO:0000250, ECO:0000269|PubMed:12011441, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18765639}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Testis specific. Specifically expressed in primary spermatocytes.

BORIS Antibody - 6890 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, mock transfected (-) or transfected with a construct overexpressing human BORIS (+), using BORIS Antibody.

BORIS (F-1) - sc-377085 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BORIS (F-1): sc-377085. Western blot analysis of BORIS expression in human testis tissue extract.

BORIS (H-120) - sc-98982 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

BORIS (N-12) - sc-51038 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

BORIS (D-13) - sc-51037 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BORIS (D-13): sc-51037. Western blot analysis of BORIS expression in K-562 (A), Jurkat (B) and U-251-MG (C) whole cell lysates.

BORIS (42.54) - sc-135729 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

BORIS (C-15) - sc-51036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

BORIS (54.47) - sc-135730 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

BORIS (S-13) - sc-51039 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-BORIS antibody - ab126778 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BORIS antibody (ab126778) at 4 µg/mlLane 1 : Jurkat cell lysateLane 2 : Jurkat cell lysateLane 3 : 3T3 cell lysateLane 4 : Rat kidney lysate

Anti-BORIS antibody - ab126766 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BORIS antibody (ab126766) at 1/200 dilutionLane 1 : Human prostate tissue lysateLane 2 : Human spleen tissue lysate

Anti-BORIS antibody [EP12204] - ab187163 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP12204
Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling BORIS with ab187163 at 1/1000 dilution, followed by prediluted HRP Polymer for Rabbit IgG. Counter stained with Hematoxylin.

Anti-CTCFL / BORIS Antibody - LS-C334525 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of MCF-7 cell using CTCFL antibody. Blue: DAPI for nuclear staining.

Anti-CTCFL / BORIS Antibody - LS-C183761 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTCFL / BORIS Antibody (aa211-260) - LS-C30143 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-CTCFL / BORIS Antibody (clone KT72) - LS-C193496 from LifeSpan Bioscience

Host Rat
Clonality Monoclonal
Clone KT72

Anti-CTCFL / BORIS Antibody (aa9-26) - LS-C19129 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-BORIS Antibody - Western Blot. Western blot of Affinity Purified anti-BORIS antibody shows detection of a predominant band corresponding to BORIS in human tissue lysates (arrowhead). Lane 1 contains lysate from human prostate tissue. Lane 2 contains lysate from human spleen tissue. A predominant band at ~75 kD is observed. Molecular weight estimation was made by comparison to prestained MW markers as indicated.

Anti-CTCFL / BORIS Antibody - LS-C341946 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTCFL / BORIS Antibody (aa36-85) - LS-C110123 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CTCFL / BORIS antibody LS-C110123 Western blot of 721_B cell lysate.

Anti-CTCFL / BORIS Antibody - LS-C147013 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CTCFL / BORIS antibody LS-C147013.

BORIS Antibody - NBP1-89947 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: BORIS Antibody [NBP1-89947] - Staining of human testis shows moderate nuclear positivity in subset of cells in seminiferous ducts.

BORIS Antibody - NB100-2028 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: BORIS Antibody [NB100-2028] - Analysis of a predominant band corresponding to BORIS in human tissue lysates (arrowhead). Lane 1 contains lysate from human prostate tissue. Lane 2 contains lysate from human spleen tissue. A predominant band at 75 kDa is observed.

CT27 Polyclonal Antibody - bs-5962R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CTCFL antibody produced in rabbit - HPA001472 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CTCFL: <B>Cat. No. HPA001472</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human gall bladder tissue showing membranous and/or cytoplasmic staining of glandular cells.

Anti-CTCFL antibody produced in rabbit - AV36127 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV36127</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.5 μg/mL in cell type Jurkat
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