CTCFL

Gene Symbol	CTCFL
Entrez Gene	140690
Alt Symbol	BORIS, CT27, CTCF-T, HMGB1L1, dJ579F20.2
Species	Human
Gene Type	protein-coding
Description	CCCTC-binding factor (zinc finger protein)-like
Other Description	BORIS-like protein|CTCF paralog|CTCF-like protein|HMG-1L1|brother of the regulator of imprinted sites|cancer/testis antigen 27|putative high mobility group protein 1-like 1|putative high mobility group protein B1-like 1|transcriptional repressor CTCFL|zinc finger protein CTCF-T
Swissprots	E9PBA9 A6XGM2 A0S6W1 A6XGL8 Q8NI51 A6XGN1 A6XGM8 A6XGN3 A1L4C6 Q9BZ30 A6XGN2 Q9NQJ3 A6XGM3 E7EUE3 A6XGN4 E7EQ27 A6XGN0 Q5JUG4
Accessions	EAW75516 EAW75517 EAW75518 Q8NI51 AF336042 AAM28645 AK128070 BAG54626 AK313990 BAG36702 AW243377 AY071919 AAL61541 BC060763 BC130486 AAI30487 BC137482 AAI37483 BC137483 AAI37484 DQ294738 ABB92839 DQ778108 ABH10090 DQ778109 ABH10091 DQ778110 ABH10092 DQ778111 ABH10093 DQ778112 ABH10094 DQ778113 ABH10095 DQ778114 ABH10096 DQ778115 ABH10097 DQ778116 ABH10098 DQ778117 ABH10099 DQ778118 ABH10100 DQ778119 ABH10101 DQ778120 ABH10102 DQ778121 ABH10103 DQ778122 ABH10104 DQ778123 ABH10105 DQ778124 ABH10106 DQ778125 ABH10107 DQ778126 ABH10108 DQ778127 ABH10109 DQ778128 ABH10110 DQ778129 ABH10111 DQ778130 ABH10112 DQ778131 ABH10113 NM_001269040 NP_001255969 NM_001269041 NP_001255970 NM_001269042 NP_001255971 NM_001269043 NP_001255972 NM_001269044 NP_001255973 NM_001269045 NP_001255974 NM_001269046 NP_001255975 NM_001269047 NP_001255976 NM_001269048 NP_001255977 NM_001269049 NP_001255978 NM_001269050 NP_001255979 NM_001269051 NP_001255980 NM_001269052 NP_001255981 NM_001269054 NP_001255983 NM_001269055 NP_001255984 NM_080618 NP_542185 NR_072975
Function	Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. {ECO:0000250, ECO:0000269|PubMed:12011441, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18765639}.
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Testis specific. Specifically expressed in primary spermatocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CTCFL overexpression lysate - LY409159 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

CTCFL 293 Cell Lysate - 404881 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

BORIS Overexpression Lysate (Native) - NBL1-09565 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

CTCFL Over-expression Lysate Product - GWB-76781C from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human CTCFL Knockdown Stable Cell Line - CSC-DC003787 from Creative biogene Category Cell Line Species Human

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