| Gene Symbol | Ccl12 |
|---|---|
| Entrez Gene | 20293 |
| Alt Symbol | MCP-5, Scya12 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 12 |
| Other Description | C-C motif chemokine 12|MCP-1-related chemokine|monocyte chemoattractant protein 5|monocyte chemotactic protein 5|small inducible cytokine A12|small-inducible cytokine A12 |
| Swissprots | Q9QYD6 Q62401 |
| Accessions | EDL01207 EDL01219 Q62401 AF065934 AAF15384 AF065935 AAF15385 AF065936 AAF15386 AF065937 AAF15387 AF065938 AAF15388 AK012356 BAB28185 BC027520 AAH27520 U50712 AAB50053 U66670 AAB49424 NM_011331 NP_035461 |
| Function | Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon. |
| Top Pathways | Chagas disease (American trypanosomiasis), Malaria, Chemokine signaling pathway, Rheumatoid arthritis, NOD-like receptor signaling pathway |