PIK3CA

Gene Symbol	PIK3CA
Entrez Gene	5290
Alt Symbol	CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Other Description	PI3-kinase p110 subunit alpha|PI3K-alpha|phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha|phosphatidylinositol 3-kinase, catalytic, alpha polypeptide|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform|phosphoinositide-3-kinase, catalytic, alpha polypeptide|ptdIns-3-kinase subunit p110-alpha|serine/threonine protein kinase PIK3CA
Swissprots	Q99762 P42336 Q14CW1
Accessions	ADQ00185 ADQ00187 CAT16714 CAV28702 CDL93485 EAW78423 P42336 AB210020 BAE06102 AK021510 AK292940 BAF85629 AK297203 BAG59688 AK302608 BAG63856 AU129890 AW445128 BC113601 AAI13602 BC113603 AAI13604 BQ228953 BX437219 BX473473 BX484734 DQ910907 ABI95433 HM437241 ADN43072 U79143 AAB39753 Z29090 CAA82333 XM_006713658 XP_006713721 XM_011512894 XP_011511196 NM_006218 NP_006209
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Reg
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse PIK3CA / PI3K Alpha ELISA Kit (Sandwich ELISA) - LS-F12339 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human PIK3CA / PI3K Alpha ELISA Kit (Sandwich ELISA) - LS-F12338 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, PIK3CA, Human, ELISA Kit - E14307h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.156-10 ng/mL

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ELISA Kit - MBS280579 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

PIP3 Quantification TR-FRET Assay - 17-494 from EMD Millipore

PI 3-Kinase HTRF™ Assay; 1920 wells - 33-017 from EMD Millipore

PI 3-Kinase 3-step HTRF™ Assay - 33-040 from EMD Millipore

PI 3-Kinase HTRF™ Assay; 385 wells - 33-016 from EMD Millipore

PI 3-Kinase 3-step HTRF™ Assay - 33-041 from EMD Millipore

PI 3-Kinase 3-step HTRF™ Assay - 33-047 from EMD Millipore

PIP3 Quantification TR-FRET Assay - 17-495 from EMD Millipore

PI 3-Kinase HTRF™ Assay; 10,000 wells - 33-036 from EMD Millipore

PI 3-Kinase HTRF™ Assay; 50,000 wells - 33-037 from EMD Millipore

PI3 Kinase Activity/Inhibitor ELISA - 17-493 from EMD Millipore

Bovine PIK3CA / PI3K Alpha ELISA Kit (Custom ELISA) - LS-F17250 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

PIK3CA - EKH3188 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

PIK3CA ELISA Kit (Human) : 96 Wells (OKEH02351) - OKEH02351 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.056 ng/mL Range 0.156 - 10 ng/mL

PIK3CA (Human) ELISA Kit - K4259 from Biovision Category ELISA Kit Prices $695.00 Sizes 100 assays

Human PIK3CA ELISA Kit - E028964 from Biobool Category ELISA Kit Sensitivity <0.094ng/ml

Human Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform ELISA Kit - EK3388 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 0.056ng/ml Range 0.156-10 ng/mL

anti-PIK3CA / P110alpha antibody - ARG64089 from Arigo Biolaboratories Category ELISA Kit

Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha isoform, ELISA Kit - MBS9427222 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 0.056ng/mL Range 0.156-10 ng/mL

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ELISA Kit - MBS2883462 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

PIK3CA, ELISA Kit - MBS846735 from MyBioSource Category ELISA Kit Prices $825.00 Sizes 100 assays Sensitivity < 0.094 ng/ml Range 0.156-10 ng/ml

Mouse PIK3CA / PI3K Alpha ELISA Kit (Sandwich ELISA) - LS-F33265 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.469 Range 0.156-10 ng/ml

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