PIK3CA

Gene Symbol	PIK3CA
Entrez Gene	5290
Alt Symbol	CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Other Description	PI3-kinase p110 subunit alpha|PI3K-alpha|phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha|phosphatidylinositol 3-kinase, catalytic, alpha polypeptide|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform|phosphoinositide-3-kinase, catalytic, alpha polypeptide|ptdIns-3-kinase subunit p110-alpha|serine/threonine protein kinase PIK3CA
Swissprots	Q99762 P42336 Q14CW1
Accessions	ADQ00185 ADQ00187 CAT16714 CAV28702 CDL93485 EAW78423 P42336 AB210020 BAE06102 AK021510 AK292940 BAF85629 AK297203 BAG59688 AK302608 BAG63856 AU129890 AW445128 BC113601 AAI13602 BC113603 AAI13604 BQ228953 BX437219 BX473473 BX484734 DQ910907 ABI95433 HM437241 ADN43072 U79143 AAB39753 Z29090 CAA82333 XM_006713658 XP_006713721 XM_011512894 XP_011511196 NM_006218 NP_006209
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Reg
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PI 3 Kinase p110 alpha + PI 3 kinase p85 alpha full length protein - ab196129 from Abcam Category Protein Prices $837.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Active human PI 3 Kinase p110 alpha + PI 3 kinase p85 alpha full length protein - ab198145 from Abcam Category Protein Prices $837.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human PI 3 Kinase catalytic subunit alpha protein fragment - ab159127 from Abcam Category Protein Source Wheat germ Species Human

PI3K(p110alpha/p55gamma) protein (Active) - ab127617 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

PIK3CA / PI3K Alpha Antibody Blocking Peptide - LS-E26212 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3CA / PI3K Alpha Antibody Blocking Peptide - LS-E9320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3CA / PI3K Alpha Antibody Blocking Peptide - LS-E9428 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PIK3CA Protein - H00005290-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PIK3CA Peptide - P2991 from Novus Biologicals Category Peptide Species Human

PIK3CA Peptide - P2990 from Novus Biologicals Category Peptide Species Human

PIK3CA Peptide - P2989 from Novus Biologicals Category Peptide Species Human

PK3CA-Antibody-Y317-Blocking-Peptide - BP7860a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3KCA-Antibody-Center-Blocking-Peptide - BP8016c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3KCA-Antibody-C-term-Blocking-Peptide - BP8016b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3KCA-Antibody-N-term-Blocking-Peptide - BP8016a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3K p110 alpha blocking peptide - GTX89196-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

PIK3CA - H00005290-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIK3CA - H00005290-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIK3CA - P5668 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 20 µg Species Human

PIK3CA Peptide - 46-186P from ProSci Category Peptide Species Human

PIK3CA fusion protein - ag16586 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PIK3CA fusion protein - Ag17392 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PI3KCA Peptide - 350481 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

PI3 kinase (p110a/p85a), Active Human Recombinant Protein GST-tag - GWB-PSBF0A from Genway Biotech Category Protein Prices $584.00 Sizes 20 µg Species Human

PI3 kinase (p110a/p85a), Active Human Recombinant Protein FLAG tag - GWB-F64C10 from Genway Biotech Category Protein Prices $584.00 Sizes 20 µg Species Human

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