| Gene Symbol | PIK3CA |
|---|---|
| Entrez Gene | 5290 |
| Alt Symbol | CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Other Description | PI3-kinase p110 subunit alpha|PI3K-alpha|phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha|phosphatidylinositol 3-kinase, catalytic, alpha polypeptide|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform|phosphoinositide-3-kinase, catalytic, alpha polypeptide|ptdIns-3-kinase subunit p110-alpha|serine/threonine protein kinase PIK3CA |
| Swissprots | Q99762 P42336 Q14CW1 |
| Accessions | ADQ00185 ADQ00187 CAT16714 CAV28702 CDL93485 EAW78423 P42336 AB210020 BAE06102 AK021510 AK292940 BAF85629 AK297203 BAG59688 AK302608 BAG63856 AU129890 AW445128 BC113601 AAI13602 BC113603 AAI13604 BQ228953 BX437219 BX473473 BX484734 DQ910907 ABI95433 HM437241 ADN43072 U79143 AAB39753 Z29090 CAA82333 XM_006713658 XP_006713721 XM_011512894 XP_011511196 NM_006218 NP_006209 |
| Function | Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Reg |
| Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |