HRAS
| Gene Symbol | HRAS |
|---|---|
| Entrez Gene | 3265 |
| Alt Symbol | C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras |
| Species | Human |
| Gene Type | protein-coding |
| Description | Harvey rat sarcoma viral oncogene homolog |
| Other Description | GTP- and GDP-binding peptide B|GTPase HRas|Ha-Ras1 proto-oncoprotein|Harvey rat sarcoma viral oncoprotein|Ras family small GTP binding protein H-Ras|c-has/bas p21 protein|c-ras-Ki-2 activated oncogene|p19 H-RasIDX protein|transformation gene: oncogene HAMSV|transforming protein p21|v-Ha-ras Harvey rat sarcoma viral oncogene homolog |
| Swissprots | Q6FHV9 B5BUA0 Q9UCE2 Q14080 Q9BR65 P01112 |
| Accessions | AAA35683 AAA35685 AAA35687 AAA36557 AAA52693 AAB02605 AAK56963 ABI97389 CAA25624 CAA34461 CAN37622 CBV35641 CDL93477 EAX02337 EAX02338 EAX02339 EAX02340 EAX02341 P01112 AB451336 BAG70150 AB451485 BAG70299 AF493916 AAM12630 AJ437024 CAD24594 BC006499 AAH06499 BC095471 AAH95471 BM801632 BQ574535 BQ674260 BT019421 AAV38228 CR536579 CAG38816 CR542271 CAG47067 DN990077 KJ534867 AHW56507 KJ534868 AHW56508 XR_242795 XR_430702 NM_001130442 NP_001123914 NM_005343 NP_005334 NM_176795 NP_789765 |
| Function | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. {ECO:0000269|PubMed:12740440, ECO:0000269|PubMed:14500341, ECO:0000269|PubMed:9020151}. |
| Subcellular Location | Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:14500341}. |
| Top Pathways | Central carbon metabolism in cancer, Axon guidance, Viral carcinogenesis, Estrogen signaling pathway, Sphingolipid signaling pathway |
H-Ras CRISPR/Cas9 KO Plasmid (h) - sc-400204 from Santa Cruz Biotechnology
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H-Ras HDR Plasmid (h) - sc-400204-HDR from Santa Cruz Biotechnology
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H-Ras Double Nickase Plasmid (h) - sc-400204-NIC from Santa Cruz Biotechnology
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H-Ras Double Nickase Plasmid (h2) - sc-400204-NIC-2 from Santa Cruz Biotechnology
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H-Ras CRISPR Activation Plasmid (h) - sc-400204-ACT from Santa Cruz Biotechnology
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H-Ras CRISPR Activation Plasmid (h2) - sc-400204-ACT-2 from Santa Cruz Biotechnology
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H-Ras Lentiviral Activation Particles (h) - sc-400204-LAC from Santa Cruz Biotechnology
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H-Ras Lentiviral Activation Particles (h2) - sc-400204-LAC-2 from Santa Cruz Biotechnology
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H-Ras siRNA (h) - sc-29340 from Santa Cruz Biotechnology
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H-Ras shRNA Plasmid (h) - sc-29340-SH from Santa Cruz Biotechnology
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H-Ras shRNA (h) Lentiviral Particles - sc-29340-V from Santa Cruz Biotechnology
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vH RAS RNAi - H00003265-R02 from Novus Biologicals
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vH RAS RNAi - H00003265-R01 from Novus Biologicals
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MISSION® esiRNA - EHU134211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1487 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1487 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01978 from Sigma-Aldrich
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HRAS siRNA (Human) - CRH2233 from Cohesion Biosciences
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HRAS - MBS829440 from MyBioSource
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shRNA set against Human HRAS (NM_005343.2) - SHH314769 from Creative biogene
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Human HRAS siRNA - orb262735 from Biorbyt
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HRAS shRNA Plasmid (Human) - CHH2233 from Cohesion Biosciences
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HRAS miRNA 3'UTR clone - MiUTR1H-04691 from Creative biogene
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HRAS miRNA 3'UTR clone - MiUTR3H-02267 from Creative biogene
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HRAS miRNA 3'UTR clone - MiUTR3H-02269 from Creative biogene
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