CEP131

Gene Symbol	CEP131
Entrez Gene	22994
Alt Symbol	AZ1, AZI1, ZA1
Species	Human
Gene Type	protein-coding
Description	centrosomal protein 131kDa
Other Description	5-azacytidine induced 1|5-azacytidine-induced protein 1|centrosomal protein 131 kDa|centrosomal protein of 131 kDa|pre-acrosome localization protein 1
Swissprots	B2RN11 Q9UPN4 A6NHI8 Q96F50
Accessions	EAW89631 EAW89632 Q9UPN4 AB029041 BAA83070 AI955901 BC010413 BC011615 AAH11615 BC012130 BC040023 BC136578 AAI36579 BC136580 AAI36581 BC144263 BE732160 BE734213 BG773915 BU742835 BX394713 XM_011524547 XP_011522849 XM_011524548 XP_011522850 XM_011524549 XP_011522851 XM_011524550 XP_011522852 XM_011524551 XP_011522853 XM_011524552 XP_011522854 XM_011524553 XP_011522855 XM_011524554 XP_011522856 XM_011524555 XP_011522857 NM_001009811 NP_001009811 NM_014984 NP_055799
Function	Component of centriolar satellites contributing to build a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole dupl
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=Colocalized with pericentriolar material protein PCM1 at centriolar satellites. During spermiogenesis, becomes enriched with nephrocystin NPHP1 at the transition zone, a structure at the base of the ciliary axoneme important for regulating traffic into the ciliary compartment. Traffics towards and away from the centrosome/basal body and the transition zone of the ciliary axoneme in a microtubule-dependent manner. Localized at the Golgi-derived acrosome and the centrosome-containing head-tail coupling apparatus (HTCA) (By similarity). Ubiquitinated form is sequestred and colocalized with BBS4, CEP290, PCM1 and PCNT at centriolar satellites in proliferating cells. Colocalized with the pericentriolar material protein PCM1

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AZI1 (G-14) - sc-163722 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AZI1 (S-13) - sc-163724 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-AZI1 antibody - ab99379 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AZI1 antibody - ab99315 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AZI1 antibody - ab84864 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AZI1 antibody - ab110018 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CEP131 / AZI1 Antibody (aa325-375) - LS-C288214 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CEP131 / AZI1 Antibody (Internal) - LS-C346027 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CEP131 / AZI1 Antibody (aa1033-1083) - LS-C288211 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CEP131 / AZI1 Antibody (aa1033-1083) - LS-C286597 from LifeSpan Bioscience Prices $415.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CEP131 / AZI1 Antibody (aa1-50) - LS-C288210 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CEP131 / AZI1 Antibody (aa311-360) - LS-C119651 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

AZ1 Antibody - NBP1-90053 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZ1 Antibody - NB100-68225 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZ1 Antibody - NB100-68227 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody - bs-12977R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12977R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12977R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12977R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12977R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody, Cy3 Conjugated - bs-12977R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody, Cy5 Conjugated - bs-12977R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody, Cy5.5 Conjugated - bs-12977R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody, Cy7 Conjugated - bs-12977R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AZI1 Polyclonal Antibody, FITC Conjugated - bs-12977R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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