| Gene Symbol | CEP131 |
|---|---|
| Entrez Gene | 22994 |
| Alt Symbol | AZ1, AZI1, ZA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | centrosomal protein 131kDa |
| Other Description | 5-azacytidine induced 1|5-azacytidine-induced protein 1|centrosomal protein 131 kDa|centrosomal protein of 131 kDa|pre-acrosome localization protein 1 |
| Swissprots | B2RN11 Q9UPN4 A6NHI8 Q96F50 |
| Accessions | EAW89631 EAW89632 Q9UPN4 AB029041 BAA83070 AI955901 BC010413 BC011615 AAH11615 BC012130 BC040023 BC136578 AAI36579 BC136580 AAI36581 BC144263 BE732160 BE734213 BG773915 BU742835 BX394713 XM_011524547 XP_011522849 XM_011524548 XP_011522850 XM_011524549 XP_011522851 XM_011524550 XP_011522852 XM_011524551 XP_011522853 XM_011524552 XP_011522854 XM_011524553 XP_011522855 XM_011524554 XP_011522856 XM_011524555 XP_011522857 NM_001009811 NP_001009811 NM_014984 NP_055799 |
| Function | Component of centriolar satellites contributing to build a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole dupl |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=Colocalized with pericentriolar material protein PCM1 at centriolar satellites. During spermiogenesis, becomes enriched with nephrocystin NPHP1 at the transition zone, a structure at the base of the ciliary axoneme important for regulating traffic into the ciliary compartment. Traffics towards and away from the centrosome/basal body and the transition zone of the ciliary axoneme in a microtubule-dependent manner. Localized at the Golgi-derived acrosome and the centrosome-containing head-tail coupling apparatus (HTCA) (By similarity). Ubiquitinated form is sequestred and colocalized with BBS4, CEP290, PCM1 and PCNT at centriolar satellites in proliferating cells. Colocalized with the pericentriolar material protein PCM1 |
AZI1 CRISPR/Cas9 KO Plasmid (h) - sc-409828 from Santa Cruz Biotechnology
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AZI1 HDR Plasmid (h) - sc-409828-HDR from Santa Cruz Biotechnology
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AZI1 Double Nickase Plasmid (h) - sc-409828-NIC from Santa Cruz Biotechnology
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AZI1 Double Nickase Plasmid (h2) - sc-409828-NIC-2 from Santa Cruz Biotechnology
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AZI1 CRISPR Activation Plasmid (h) - sc-409828-ACT from Santa Cruz Biotechnology
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AZI1 CRISPR Activation Plasmid (h2) - sc-409828-ACT-2 from Santa Cruz Biotechnology
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AZI1 Lentiviral Activation Particles (h) - sc-409828-LAC from Santa Cruz Biotechnology
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AZI1 Lentiviral Activation Particles (h2) - sc-409828-LAC-2 from Santa Cruz Biotechnology
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AZI1 siRNA (h) - sc-94024 from Santa Cruz Biotechnology
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AZI1 shRNA Plasmid (h) - sc-94024-SH from Santa Cruz Biotechnology
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AZI1 shRNA (h) Lentiviral Particles - sc-94024-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU031981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3789 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3789 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00222 from Sigma-Aldrich
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AZI1 siRNA (Human) - CRH7916 from Cohesion Biosciences
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AZI1 - MBS8222647 from MyBioSource
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shRNA set against Human AZI1 (NM_001009811.2) - SHH244014 from Creative biogene
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shRNA set against Human AZI1(NM_001009811.2) - SHG087877 from Creative biogene
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shRNA set against Human AZI1(NM_014984.2) - SHG087895 from Creative biogene
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Human AZI1 siRNA - orb268418 from Biorbyt
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AZI1 shRNA Plasmid (Human) - CHH7916 from Cohesion Biosciences
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AZI1 miRNA 3'UTR clone - MiUTR1H-00756 from Creative biogene
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AZI1 miRNA 3'UTR clone - MiUTR1H-00757 from Creative biogene
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