SRY

Gene Symbol SRY
Entrez Gene 6736
Alt Symbol SRXX1, SRXY1, TDF, TDY
Species Human
Gene Type protein-coding
Description sex determining region Y
Other Description essential protein for sex determination in human males|sex determining region Y protein|sex-determining region Y protein|sex-determining region on Y|testis-determining factor on Y
Swissprots Q05066
Accessions AAA16878 AAA60591 AAP88266 AAP88268 AAP88269 AAP88270 AAS79428 AAT37461 AAT37462 AAT39011 AAT39012 AAT39013 AAT39014 AAT39015 AAT39016 AAT39017 AAT39018 AAT39019 AAV65019 AAV65116 AAX93511 AAX93512 AAX93513 AAY15119 AAY15120 AAY15121 AAY15122 AAY15123 AAY88211 AAY88212 ACY42637 ACY42638 ACY42639 ACY42640 ADG26743 ADG26744 ADJ00507 ADJ00508 ADJ00509 ADJ00510 ADJ00511 ADJ00512 ADJ00513 ADJ00514 ADJ00515 ADJ00516 ADJ00517 ADJ00518 ADJ37112 ADJ37113 ADJ37114 ADJ37115 ADJ37116 ADJ37117 AEK31547 AEK31548 AEK31549 AEK31550 AEK31551 AFG33929 AFG33930 AFG33931 AFG33932 AFG33933 AFG33934 AFG33935 AFG33936 AFG33937 AFG33938 AFG33939 AFG33940 AFG33941 AFG33942 AFG33943 AFG33944 AFG33945 AFG33946 AFG33947 AFG33948 AFG33949 AFG33950 AFG33951 AFG33952 AFG33953 AFG33954 AFG33955 AGZ62969 AGZ62970 AGZ62971 AGZ62972 AGZ62973 AGZ62974 AGZ62975 AGZ62977 CAA37790 CAA65281 CAD13147 CAP05197 CAP05198 CAP05199 CAP05200 CAP05201 CAP05202 CBH40188 CBH40189 CBH40190 CBH40191 CBH40192 CBH40193 CBH40194 CBH40195 CBH40196 CBH40197 CBH40198 CBH40199 CBH40200 CBH40201 CBH40202 CBH40203 CBH40204 CBH40205 CBH40206 CBH40207 CBH40208 CBH40209 Q05066 BC074923 AAH74923 BC074924 AAH74924 EU446863 ABZ92392 L10101 AAA60590 S53156 AAB25008 S56543 AAB25716 NM_003140 NP_003131
Function Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. {ECO:0000250, ECO:0000269|PubMed:11563911, ECO:0000269|PubMed:11818535, ECO:0000269|PubMed:15170344, ECO:0000269|PubMed:16762365}.
Subcellular Location Nucleus speckle. Cytoplasm. Note=Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus. Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). {ECO:0000250}.

SRY (H-1) - sc-374224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRY (H-1): sc-374224. Western blot analysis of SRY expression in non-transfected (A) and human SRY transfected (B) CMV whole cell lysates.

SRY (C-17) - sc-8234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SRY (H-60) - sc-33168 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

SRY (SRY-15) - sc-69842 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRY (SRY-15): sc-69842. Western blot analysis of SRY expression in human testis tissue extract (A) and NTERA-2 cl.D1 whole cell lysate (B).

SRY (N-19)-R - sc-8232-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
SRY (N-19)-R: sc-8232-R. Western blot analysis of SRY expression in non-transfected: sc-117752 (A) and mouse SRY transfected: sc-370070 (B) 293T whole cell lysates.

Anti-SRY antibody - ab167619 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SRY antibody (ab167619) at 1 µg/mlLane 1 : SRY transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-SRY antibody - ab85357 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SRY antibody (ab85357) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SRY antibody - ab99264 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SRY antibody (ab99264) at 1 µg/ml + Testis (Human) Tissue Lysate - adult normal tissue (ab30257) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SRY antibody - ab138264 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SRY antibody (ab138264) at 1/500 dilution + K562 cell lysate at 30 µg

Anti-SRY antibody [1G4] - ab135239 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G4
Anti-SRY antibody [1G4] (ab135239) at 1/500 dilution + Human SRY recombinant protein

Anti-SRY antibody [3C8] - ab140309 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C8
Immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SRY, labelling SRY with ab140309 at 1/100 dilution.

Anti-SRY Antibody (clone 3C8) - LS-C337844 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C8
Anti-SRY mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SRY.

Anti-SRY Antibody (clone 1F10/A1) - LS-C91674 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F10/A1

Anti-SRY Antibody (clone SRY.G12) - LS-C136781 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone SRY.G12

Anti-SRY Antibody - LS-C285616 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SRY Antibody (aa1-204) - LS-C311487 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SRY Antibody (Biotin) - LS-C317114 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SRY Antibody (FITC) - LS-C317117 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SRY Antibody (aa51-100) - LS-C118991 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa cells, using SRY Antibody. The lane on the right is treated with the synthesized peptide.

Anti-SRY Antibody (HRP) - LS-C318771 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SRY Antibody (Leu80) - LS-C176798 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SRY (L80) pAb in extracts from HeLa cells.

Anti-SRY Antibody (C-Terminus) - LS-C101518 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SRY antibody LS-C101518 Western blot of HepG2 cell lysate.

Anti-SRY Antibody (clone 2C7) - LS-C174165 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SRY (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SRY.

Anti-SRY Antibody (clone 1H10) - LS-C174164 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SRY (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SRY.

Anti-SRY Antibody (aa31-80) - LS-C200724 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from K562 cells using SRY antibody.
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