SRY

Gene Symbol	SRY
Entrez Gene	6736
Alt Symbol	SRXX1, SRXY1, TDF, TDY
Species	Human
Gene Type	protein-coding
Description	sex determining region Y
Other Description	essential protein for sex determination in human males|sex determining region Y protein|sex-determining region Y protein|sex-determining region on Y|testis-determining factor on Y
Swissprots	Q05066
Accessions	AAA16878 AAA60591 AAP88266 AAP88268 AAP88269 AAP88270 AAS79428 AAT37461 AAT37462 AAT39011 AAT39012 AAT39013 AAT39014 AAT39015 AAT39016 AAT39017 AAT39018 AAT39019 AAV65019 AAV65116 AAX93511 AAX93512 AAX93513 AAY15119 AAY15120 AAY15121 AAY15122 AAY15123 AAY88211 AAY88212 ACY42637 ACY42638 ACY42639 ACY42640 ADG26743 ADG26744 ADJ00507 ADJ00508 ADJ00509 ADJ00510 ADJ00511 ADJ00512 ADJ00513 ADJ00514 ADJ00515 ADJ00516 ADJ00517 ADJ00518 ADJ37112 ADJ37113 ADJ37114 ADJ37115 ADJ37116 ADJ37117 AEK31547 AEK31548 AEK31549 AEK31550 AEK31551 AFG33929 AFG33930 AFG33931 AFG33932 AFG33933 AFG33934 AFG33935 AFG33936 AFG33937 AFG33938 AFG33939 AFG33940 AFG33941 AFG33942 AFG33943 AFG33944 AFG33945 AFG33946 AFG33947 AFG33948 AFG33949 AFG33950 AFG33951 AFG33952 AFG33953 AFG33954 AFG33955 AGZ62969 AGZ62970 AGZ62971 AGZ62972 AGZ62973 AGZ62974 AGZ62975 AGZ62977 CAA37790 CAA65281 CAD13147 CAP05197 CAP05198 CAP05199 CAP05200 CAP05201 CAP05202 CBH40188 CBH40189 CBH40190 CBH40191 CBH40192 CBH40193 CBH40194 CBH40195 CBH40196 CBH40197 CBH40198 CBH40199 CBH40200 CBH40201 CBH40202 CBH40203 CBH40204 CBH40205 CBH40206 CBH40207 CBH40208 CBH40209 Q05066 BC074923 AAH74923 BC074924 AAH74924 EU446863 ABZ92392 L10101 AAA60590 S53156 AAB25008 S56543 AAB25716 NM_003140 NP_003131
Function	Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. {ECO:0000250, ECO:0000269|PubMed:11563911, ECO:0000269|PubMed:11818535, ECO:0000269|PubMed:15170344, ECO:0000269|PubMed:16762365}.
Subcellular Location	Nucleus speckle. Cytoplasm. Note=Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus. Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cow SRY full length protein - ab181928 from Abcam Category Protein Prices $530.00 Sizes 10 µg Source E. coli Species Bovine

Human SRY full length protein - ab132257 from Abcam Category Protein Source Wheat germ Species Human

Human SRY peptide - ab50451 from Abcam Category Peptide Species Human

SRY Antibody Blocking Peptide - LS-E12396 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SRY Protein - H00006736-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SRY Blocking Peptide - abx063297 from Abbexa Category Peptide Species Human

SRY / TDF - H00006736-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SRY / TDF - H00006736-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SRY fusion protein - Ag12610 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

SRY fusion protein - Ag12360 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Sex Determining Region Y (SRY) - RPG341Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

SRY Blocking Peptide - CBP2103 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

SRY (L80) Peptide - BS2037P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Sex Determining Region Y (SRY) - RPG341Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Sex Determining Region Y Protein (Recombinant) - abx166884 from Abbexa Category Protein Source Human Species Human

SRY Antibody - SH-A15957 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human

SRY-Blocking-Peptide-Center - BP21539c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRY-Blocking-Peptide-N-Term - BP21504a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRY Peptide, Human - M34GP15189H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Sex Determining Region Y (SRY) - RPU52722 from Biomatik Category Protein Prices $189.00, $387.00, $592.00, $705.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

SRY Recombinant Protein (OPCD07197) - OPCD07197 from Aviva Systems Biology Category Protein Source E.coli Species Human

Sex Determining Region Y Box Protein 18, Recombinant Protein - MBS2028955 from MyBioSource Category Protein Prices $205.00, $450.00, $705.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Rat

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