RIF1

Gene Symbol RIF1
Entrez Gene 55183
Alt Symbol -
Species Human
Gene Type protein-coding
Description replication timing regulatory factor 1
Other Description RAP1 interacting factor homolog|rap1-interacting factor 1 homolog|telomere-associated protein RIF1
Swissprots Q9Y4R4 Q9H9B9 A6NC27 Q5UIP0 Q6PRU2 C9JBR1 Q99772 Q9NVP5 Q5H9R3 Q8TE94 Q9H830 Q66YK6 Q5UIP2
Accessions EAX11507 EAX11508 EAX11509 EAX11510 Q5UIP0 AK000323 AK001461 BAA91705 AK022932 BAB14313 AK024033 BAB14792 AK074349 BAB85058 AK299291 BAG61306 AK299572 BAG61511 AL080129 CAB45727 AL137363 AY584066 AAS94233 AY585745 AAT40745 AY727910 AAV51401 AY727911 AAV51402 AY727912 AAV51403 AY727913 AAV51404 BC072675 BC172393 AAI72393 BX648324 CR933663 CAI45961 U79263 AAB50209 XM_005246665 XP_005246722 XM_011511393 XP_011509695 XM_011511394 XP_011509696 XM_011511395 XP_011509697 XR_922954 XR_922955 XR_922956 XR_922957 NM_001177663 NP_001171134 NM_001177664 NP_001171135 NM_001177665 NP_001171136 NM_018151 NP_060621
Function Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S- phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints. {ECO:0000269|PubMed:15342490}.
Subcellular Location Nucleus. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Note=Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase.
Tissue Specificity Highly expressed in testis. {ECO:0000269|PubMed:15583028}.
Top Pathways Signaling pathways regulating pluripotency of stem cells

Rif1 CRISPR/Cas9 KO Plasmid (h) - sc-417998 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rif1 HDR Plasmid (h) - sc-417998-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rif1 Double Nickase Plasmid (h) - sc-417998-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rif1 Double Nickase Plasmid (h2) - sc-417998-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rif1 CRISPR Activation Plasmid (h) - sc-417998-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rif1 CRISPR Activation Plasmid (h2) - sc-417998-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rif1 Lentiviral Activation Particles (h) - sc-417998-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rif1 Lentiviral Activation Particles (h2) - sc-417998-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rif1 siRNA (h) - sc-62944 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rif1 shRNA Plasmid (h) - sc-62944-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rif1 shRNA (h) Lentiviral Particles - sc-62944-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU095481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18275 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18275 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07095 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07095

RIF1 siRNA (Human) - CRJ0536 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RIF1 - MBS8217874 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human RIF1 siRNA - orb271037 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RIF1 shRNA Plasmid (Human) - CHJ0536 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RIF1 miRNA 3'UTR clone - MiUTR3H-10327 from Creative biogene

Species Reactivities Human
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