| Gene Symbol |
NANOG
|
| Entrez Gene |
79923
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Nanog homeobox
|
| Other Description |
homeobox protein NANOG|homeobox transcription factor Nanog|homeobox transcription factor Nanog-delta 48
|
| Swissprots |
D3DUU4 Q6JZS5 Q2TTG0 Q9H9S0
|
| Accessions |
AFP90963 AFP90964 AFP90965 AFP90966 AFP90967 AFP90968 AFP90969 AFP90970 AFP90971 AFP90972 AFP90973 AFP90974 AFP90975 AFP90976 AFP90977 AFP90978 AFP90979 AFP90980 AFP90981 AFP90982 AFP90983 AFP90984 AFP90985 AFP90986 AFP90987 AFP90988 AFP90989 AFP90990 AFP90991 AFP90992 AFP90993 AFP90994 AFP90995 AFP90996 AFP90997 AFP90998 AFP90999 AFP91000 AFP91001 AFP91002 AFP91003 AFP91004 AFP91005 AFP91006 AFP91007 AFP91008 AFP91009 AFP91010 AFP91011 AFP91012 AFP91013 AFP91014 AFP91015 AFP91016 AFP91017 AFP91018 AFP91019 AFP91020 AFP91021 AFP91022 AFP91023 AFP91024 AFP91025 AFP91026 AFP91027 AFP91028 AFP91029 AFP91030 AFP91031 AFP91032 AFP91033 AFP91034 AFP91035 AFP91036 AFP91037 AFP91038 AFP91039 AFP91040 AFP91041 AFP91042 AFP91043 AFP91044 AFP91045 AFP91046 AFP91047 AFP91048 AFP91049 AFP91050 AFP91051 AFP91052 AFP91053 AFP91054 AFP91055 AFP91056 CAH25962 EAW88649 EAW88650 EAW88651 Q9H9S0 AB093576 BAC76999 AI656990 AK022643 BAB14151 AK290896 BAF83585 AY230262 AAP49529 AY578089 AAT81526 BC069807 BC098275 BC099704 BC160187 AAI60187 DC425336 EU446847 ABZ92376 XM_011520850 XP_011519152 XM_011520851 XP_011519153 XM_011520852 XP_011519154 NM_001297698 NP_001284627 NM_024865 NP_079141
|
| Function |
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:15983365}.
|
| Tissue Specificity |
Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes. {ECO:0000269|PubMed:12787504, ECO:0000269|PubMed:12787505, ECO:0000269|PubMed:14990856, ECO:0000269|PubMed:15982323, ECO:0000269|PubMed:16391521}.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells, Proteoglycans in cancer
|
