Gene Symbol | NUBP2 |
---|---|
Entrez Gene | 10101 |
Alt Symbol | CFD1, NBP 2, NUBP1 |
Species | Human |
Gene Type | protein-coding |
Description | nucleotide binding protein 2 |
Other Description | cytosolic Fe-S cluster assembly factor NUBP2|homolog of yeast cytosolic Fe-S cluster deficient 1|nucleotide binding protein 2 (MinD homolog, E. coli) |
Swissprots | Q9NWB2 D3DU80 Q9Y5Y2 |
Accessions | CAC36077 EAW85613 EAW85614 EAW85615 EAW85616 EAW85617 Q9Y5Y2 AF118394 AAD45242 AK001023 BAA91471 AK093593 AK124460 AK300696 BAH13326 AK315611 BAG37980 BC002768 AAH02768 BC008005 AAH08005 BF439443 BI196883 BU189242 BU680530 BX446436 BX648907 Z36821 XM_005255027 XP_005255084 XM_005255028 XP_005255085 XM_005255030 XP_005255087 XM_011522338 XP_011520640 NM_001284501 NP_001271430 NM_001284502 NP_001271431 NM_012225 NP_036357 NR_104318 |
Function | Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. {ECO:0000255|HAMAP-Rule:MF_03039}. |
Subcellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03039}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03039}. Note=Enriched at the centrosomes during mitosis. {ECO:0000255|HAMAP-Rule:MF_03039}. |
Tissue Specificity | Widely expressed with highest expression in skeletal muscle. |