SMG7

Gene Symbol SMG7
Entrez Gene 9887
Alt Symbol C1orf16, EST1C, SGA56M
Species Human
Gene Type protein-coding
Description SMG7 nonsense mediated mRNA decay factor
Other Description EST1 telomerase component homolog C|EST1-like protein C|breast cancer-associated antigen SGA-56M|ever shorter telomeres 1C|protein SMG7|smg-7 homolog, nonsense mediated mRNA decay factor
Swissprots Q7Z7H9 E9PCI0 Q8IXC2 B4DRB2 Q92540 Q8IXC1 Q5T1Q0 Q6PIE0 E9PEH2
Accessions EAW91154 EAW91155 EAW91156 EAW91157 EAW91158 EAW91159 Q92540 AB085674 BAC53621 AK056035 BAB71079 AK074297 AK091477 BAC03672 AK297207 BAG59692 AK299178 BAG61224 AK307394 AL833675 AY386363 AAR25620 BC009281 BC015788 BC036381 AAH36381 BC052565 AAH52565 BM152501 CN479993 D87437 BAA13381 DB223038 DC380923 XM_005245648 XP_005245705 XM_005245649 XP_005245706 XM_005245652 XP_005245709 XM_005245653 XP_005245710 XM_006711676 XP_006711739 XM_006711678 XP_006711741 XM_011510205 XP_011508507 XM_011510206 XP_011508508 XM_011510207 XP_011508509 XM_011510208 XP_011508510 XM_011510209 XP_011508511 XM_011510210 XP_011508512 XM_011510211 XP_011508513 NM_001174061 NP_001167532 NM_173156 NP_775179 NM_201568 NP_963862 NM_201569 NP_963863 NM_014837
Function Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}.
Subcellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
Top Pathways mRNA surveillance pathway

SMG7 (A-13) - sc-50986 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SMG7 (E-14) - sc-50988 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SMG7 (N-16) - sc-50989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SMG7 (H-300) - sc-134857 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-SMG7 antibody - ab64847 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SMG7 antibody (ab64847) at 1/500 dilutionLane 1 : Extracts from HeLa cells at 5 µgLane 2 : Extracts of Jurkat cells at 5 µgLane 3 : Extracts of 293 cells at 5 µgLane 4 : Extracts of HUVEC cells at 5 µgLane 5 : Extracts of HUVEC cells plus blocking peptide at 5 µg

Anti-SMG7 antibody - ab126984 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SMG7 antibody (ab126984) at 1/1000 dilution + NT2D1 cell lysate at 30 µg

Anti-SMG7 antibody - ab199395 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SMG7 antibody (ab199395) at 1/500 dilution + 293 cell lysate

Anti-SMG7 antibody - ab36767 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMG7 antibody - C-terminal - ab202380 from Abcam

Prices $359.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SMG7 antibody - C-terminal (ab202380) at 1/1000 dilutionLane 1 : HT29 cell lysateLane 2 : Jurkat cell lysateLane 3 : MCF7 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat anti-Rabbit IgG H&L (HRP) at 1/10000 dilution

Anti-SMG7 Antibody (Lys548) - LS-C191987 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMG7 Antibody (aa1087-1137) - LS-C288924 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMG7 Antibody (aa521-570) - LS-C119181 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HepG2 cells, using SMG7 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-SMG7 Antibody - LS-C155648 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded HeLa xenograft, using SMG7 antibody antibody at 1:500 dilution.

Anti-SMG7 Antibody (aa896-930) - LS-C344489 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysates from HT-29, Jurkat, MCF-7 cell line (from left to right) with SMG7 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.

SMG7 Antibody - NBP1-88486 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SMG7 Antibody - NBP1-22967 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SMG7 Antibody [NBP1-22967] - Western Blot and Immunoprecipitation: by Western Blot : Whole cell lysate from HeLa, 293T and mouse NIH3T3 cells. SMG7 was also immunoprecipitated byanother rabbit anti-SMG7 antibody.

SMG7 Antibody - NBP2-20423 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMG7 antibody produced in rabbit - SAB4503724 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-SMG7: <B>Cat. No. SAB4503724</B>: Immunofluorescence of HepG2 cells using Anti-SMG7 antibody. Cells on the left were treated with the Anti-SMG7 antibody. Cells on the right (negative control) were treated with both Anti-SMG7 antibody and the synthesized immunogen peptide.

Anti-SMG7 antibody produced in rabbit - SAB2701517 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SMG7: <B>Cat. No. SAB2701517</B>: Immunohistochemical analysis of paraffin-embedded HeLa xenograft, using SMG7 antibody antibody at 1:250 dilution.

SMG7-Antibody-C-term - AP20918c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from HT-29, Jurkat, MCF-7 cell line (from left to right), using SMG7 Antibody (C-term)(Cat. #AP20918c). AP20918c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.

SMG7 Antibody (OAAF02582) - OAAF02582 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SMG7 antibody - 70R-32041 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SMG7 Antibody - abx013730 from Abbexa

Host Rabbit
Clonality Polyclonal

SMG7 Antibody - abx008379 from Abbexa

Host Rabbit
Clonality Polyclonal

Anti-SMG7 (K548) - 31-B2112 from ARP American Research Products

Prices $169.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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