| Gene Symbol |
SMG7
|
| Entrez Gene |
9887
|
| Alt Symbol |
C1orf16, EST1C, SGA56M
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SMG7 nonsense mediated mRNA decay factor
|
| Other Description |
EST1 telomerase component homolog C|EST1-like protein C|breast cancer-associated antigen SGA-56M|ever shorter telomeres 1C|protein SMG7|smg-7 homolog, nonsense mediated mRNA decay factor
|
| Swissprots |
Q7Z7H9 E9PCI0 Q8IXC2 B4DRB2 Q92540 Q8IXC1 Q5T1Q0 Q6PIE0 E9PEH2
|
| Accessions |
EAW91154 EAW91155 EAW91156 EAW91157 EAW91158 EAW91159 Q92540 AB085674 BAC53621 AK056035 BAB71079 AK074297 AK091477 BAC03672 AK297207 BAG59692 AK299178 BAG61224 AK307394 AL833675 AY386363 AAR25620 BC009281 BC015788 BC036381 AAH36381 BC052565 AAH52565 BM152501 CN479993 D87437 BAA13381 DB223038 DC380923 XM_005245648 XP_005245705 XM_005245649 XP_005245706 XM_005245652 XP_005245709 XM_005245653 XP_005245710 XM_006711676 XP_006711739 XM_006711678 XP_006711741 XM_011510205 XP_011508507 XM_011510206 XP_011508508 XM_011510207 XP_011508509 XM_011510208 XP_011508510 XM_011510209 XP_011508511 XM_011510210 XP_011508512 XM_011510211 XP_011508513 NM_001174061 NP_001167532 NM_173156 NP_775179 NM_201568 NP_963862 NM_201569 NP_963863 NM_014837
|
| Function |
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
|
| Top Pathways |
mRNA surveillance pathway
|