Gene Symbol | CAMK2N2 |
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Entrez Gene | 94032 |
Alt Symbol | CAM-KIIN, CAMKIIN |
Species | Human |
Gene Type | protein-coding |
Description | calcium/calmodulin-dependent protein kinase II inhibitor 2 |
Other Description | CaM-KII inhibitory protein |
Swissprots | Q96S95 |
Accessions | EAW78280 EAW78281 Q96S95 AY037149 AAK67630 BC105077 AAI05078 BC105079 AAI05080 NM_033259 NP_150284 |
Function | Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2. {ECO:0000269|PubMed:11444830}. |
Subcellular Location | Nucleus. Cytoplasm, cytosol. Note=Excluded from nucleus when coexpressed with activated CAMK2. {ECO:0000250}. |
Tissue Specificity | Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitt's lymphoma Raji. Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells. Weakly expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells. {ECO:0000269|PubMed:11444830}. |
CaMK2N2 CRISPR/Cas9 KO Plasmid (h) - sc-413990 from Santa Cruz Biotechnology
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CaMK2N2 HDR Plasmid (h) - sc-413990-HDR from Santa Cruz Biotechnology
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CaMK2N2 Double Nickase Plasmid (h) - sc-413990-NIC from Santa Cruz Biotechnology
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CaMK2N2 Double Nickase Plasmid (h2) - sc-413990-NIC-2 from Santa Cruz Biotechnology
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CaMK2N2 CRISPR Activation Plasmid (h) - sc-413990-ACT from Santa Cruz Biotechnology
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CaMK2N2 CRISPR Activation Plasmid (h2) - sc-413990-ACT-2 from Santa Cruz Biotechnology
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CaMK2N2 Lentiviral Activation Particles (h) - sc-413990-LAC from Santa Cruz Biotechnology
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CaMK2N2 Lentiviral Activation Particles (h2) - sc-413990-LAC-2 from Santa Cruz Biotechnology
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CaMKIIN2 siRNA (h) - sc-78404 from Santa Cruz Biotechnology
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CaMKIIN2 shRNA Plasmid (h) - sc-78404-SH from Santa Cruz Biotechnology
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CaMKIIN2 shRNA (h) Lentiviral Particles - sc-78404-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5320 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5320 from Sigma-Aldrich
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CAMK2N2 siRNA (Human) - CRJ4241 from Cohesion Biosciences
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CAMK2N2 - MBS8218460 from MyBioSource
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shRNA set against Human CAMK2N2 (NM_033259.2) - SHH254045 from Creative biogene
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shRNA set against Human CAMK2N2(NM_033259.2) - SHG138493 from Creative biogene
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Human CAMK2N2 siRNA - orb274742 from Biorbyt
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CAMK2N2 shRNA Plasmid (Human) - CHJ4241 from Cohesion Biosciences
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CAMK2N2 miRNA 3'UTR clone - MiUTR1H-01637 from Creative biogene
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