HBEGF
| Gene Symbol | HBEGF |
|---|---|
| Entrez Gene | 1839 |
| Alt Symbol | DTR, DTS, DTSF, HEGFL |
| Species | Human |
| Gene Type | protein-coding |
| Description | heparin-binding EGF-like growth factor |
| Other Description | diphtheria toxin receptor (heparin-binding EGF-like growth factor)|diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)|heparin-binding epidermal growth factor|proheparin-binding EGF-like growth factor |
| Swissprots | B2R821 Q99075 |
| Accessions | AAA50562 AAA50563 AAA50564 AAC15470 AAN46738 CAV28318 EAW62069 Q99075 AK222688 BAD96408 AK307310 AK313202 BAG36018 BC033097 AAH33097 D55114 EU832647 ACE87738 EU832724 ACE87056 M60278 AAA35956 NM_001945 NP_001936 |
| Function | Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. |
| Subcellular Location | Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor. |
| Top Pathways | GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Proteoglycans in cancer |
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