HBEGF

Gene Symbol	HBEGF
Entrez Gene	1839
Alt Symbol	DTR, DTS, DTSF, HEGFL
Species	Human
Gene Type	protein-coding
Description	heparin-binding EGF-like growth factor
Other Description	diphtheria toxin receptor (heparin-binding EGF-like growth factor)|diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)|heparin-binding epidermal growth factor|proheparin-binding EGF-like growth factor
Swissprots	B2R821 Q99075
Accessions	AAA50562 AAA50563 AAA50564 AAC15470 AAN46738 CAV28318 EAW62069 Q99075 AK222688 BAD96408 AK307310 AK313202 BAG36018 BC033097 AAH33097 D55114 EU832647 ACE87738 EU832724 ACE87056 M60278 AAA35956 NM_001945 NP_001936
Function	Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Subcellular Location	Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.
Top Pathways	GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HB EGF full length protein - ab167830 from Abcam Category Protein Source E. coli Species Human

Human HB EGF peptide - ab104379 from Abcam Category Peptide

HBEGF / HB EGF Antibody Blocking Peptide - LS-E3622 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HB-EGF Protein - NBP2-34920 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,299.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

HB-EGF Protein - NBP2-23117 from Novus Biologicals Category Protein Prices $309.00 Sizes 50 µg Species Human

HBEGF-Antibody-Center-Blocking-Peptide - BP14829c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HB EGF recombinant protein - GTX53833 from GeneTex Category Protein Prices $199.00 Sizes 50 μg Source E. Coli

Recombinant Human HB-EGF - 259-HE-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Asp63-Leu148

Recombinant Human HB-EGF - 259-HE-250 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Asp63-Leu148

Recombinant Human HB-EGF, CF - 259-HE-050/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Asp63-Leu148

Recombinant Human HB-EGF, CF - 259-HE-250/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Asp63-Leu148

Human HB-EGF protein - orb168467 from Biorbyt Category Protein Prices $187.00, $323.00, $1,598.00 Sizes 10 μg, 50 μg, 1 mg Species Human

Human HBEGF protein - orb84576 from Biorbyt Category Protein Prices $162.00, $196.00, $323.00, $434.00 Sizes 5 μg, 10 μg, 50 μg, 100 μg Source Insect Species Human

HBEGF protein (His tag) - 80R-2915 from Fitzgerald Category Protein Prices $275.00 Sizes 50 µg Source E.coli

Human HBEGF Protein - abx067062 from Abbexa Category Protein Source E.coli Species Human

HBEGF (63-148, His-tag) - AR51034PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

HBEGF (63-148, His-tag) - AR51034PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

HBEGF - H00001839-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HBEGF - H00001839-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HBEGF - P6018 from Acris Antibodies Category Protein Prices $430.00 Sizes 50 µg Species Human

Proheparin-Binding EGF-like Growth Factor, Human Recombinant - 228-11988-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human Proheparin-Binding EGF-like Growth Factor - 228-11988-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Proheparin-Binding EGF-like Growth Factor - 228-11988-3 from RayBiotech Category Protein Prices $1,600.00 Sizes 3 µg Source Escherichia Coli. Species Human

HB-EGF, Human, Recombinant - 28-10173 from ARP American Research Products Category Protein Prices $99.00, $100.00, $199.00 Sizes 10 µg, 1 mg, 50 µg Source E. Coli Species Human

HBEGF, 63-148aa, Human, His tag, E.coli - 01-P2210 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Search more