| Gene Symbol |
BATF3
|
| Entrez Gene |
55509
|
| Alt Symbol |
JDP1, JUNDM1, SNFT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
basic leucine zipper transcription factor, ATF-like 3
|
| Other Description |
21 kDa small nuclear factor isolated from T-cells|21-kD small nuclear factor isolated from T cells|B-ATF-3|Jun dimerization protein 1|Jun dimerization protein p21SNFT|basic leucine zipper transcriptional factor ATF-like 3
|
| Swissprots |
Q9NR55
|
| Accessions |
EAW93381 Q9NR55 AF255346 AAF73966 AK093671 AK094854 BC117489 AAI17490 BC117491 AAI17492 BG184570 HQ258061 ADR82815 XR_921869 NM_018664 NP_061134
|
| Function |
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. {ECO:0000250, ECO:0000269|PubMed:10878360, ECO:0000269|PubMed:12087103, ECO:0000269|PubMed:15467742}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:12087103}.
|