| Gene Symbol |
EOMES
|
| Entrez Gene |
8320
|
| Alt Symbol |
TBR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eomesodermin
|
| Other Description |
T-box brain protein 2|eomesodermin homolog
|
| Swissprots |
Q8TAZ2 B7Z4I2 Q9UPM7 G3XAI5 B7ZA51 O95936
|
| Accessions |
CAB37939 CAY55962 CBX47638 EAW64387 EAW64388 O95936 AB031038 BAA83417 AK297389 BAH12568 AK297461 BAH12586 AK299499 BAH13052 AK299695 BAH13105 AK316166 BAH14537 BC025363 AAH25363 BC037568 BC131712 BM720063 BX096900 XM_005265510 XP_005265567 NM_001278182 NP_001265111 NM_001278183 NP_001265112 NM_005442 NP_005433
|
| Function |
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in CD8+ T-cells. {ECO:0000269|PubMed:17566017}.
|