| Gene Symbol |
DNAJC10
|
| Entrez Gene |
54431
|
| Alt Symbol |
ERdj5, JPDI, MTHr, PDIA19
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DnaJ (Hsp40) homolog, subfamily C, member 10
|
| Other Description |
ER-resident protein ERdj5|J-domain-containing protein disulfide isomerase-like protein|dnaJ homolog subfamily C member 10|endoplasmic reticulum DNA J domain-containing protein 5|macrothioredoxin|protein disulfide isomerase family A, member 19
|
| Swissprots |
Q86T61 Q53QT7 Q9NSY6 Q8NC82 Q8TD87 Q17RJ6 Q3B7W8 Q8IXB1 Q96K44 Q96K54 Q96K38 Q4ZG06 Q6UWZ6
|
| Accessions |
AAG32626 AAX88931 AAY24240 EAX10959 EAX10960 EAX10961 EAX10962 EAX10963 EAX10964 Q8IXB1 AA651917 AF038503 AAN73271 AF314529 AAQ14565 AF490904 AAM09527 AK027450 BAB55121 AK027647 BAB55263 AK027696 BAB55304 AK027701 BAG51367 AK074905 BAC11281 AK298138 BAG60416 AL137648 CAB70858 AL832267 AL832632 AL832646 CAD89982 AY089971 AAM09954 AY358577 AAQ88940 BC034713 AAH34713 BC070034 BC107425 AAI07426 BC117299 AAI17300 BC126168 AAI26169 DA106532 HQ258514 ADR83268 HQ258651 ADR83402 NM_001271581 NP_001258510 NM_018981 NP_061854 NR_073365 NR_073366 NR_073367
|
| Function |
Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. {ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:18400946, ECO:0000269|PubMed:19122239, ECO:0000269|PubMed:23769672}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:23769672}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|