DNAJC10

Gene Symbol	DNAJC10
Entrez Gene	54431
Alt Symbol	ERdj5, JPDI, MTHr, PDIA19
Species	Human
Gene Type	protein-coding
Description	DnaJ (Hsp40) homolog, subfamily C, member 10
Other Description	ER-resident protein ERdj5|J-domain-containing protein disulfide isomerase-like protein|dnaJ homolog subfamily C member 10|endoplasmic reticulum DNA J domain-containing protein 5|macrothioredoxin|protein disulfide isomerase family A, member 19
Swissprots	Q86T61 Q53QT7 Q9NSY6 Q8NC82 Q8TD87 Q17RJ6 Q3B7W8 Q8IXB1 Q96K44 Q96K54 Q96K38 Q4ZG06 Q6UWZ6
Accessions	AAG32626 AAX88931 AAY24240 EAX10959 EAX10960 EAX10961 EAX10962 EAX10963 EAX10964 Q8IXB1 AA651917 AF038503 AAN73271 AF314529 AAQ14565 AF490904 AAM09527 AK027450 BAB55121 AK027647 BAB55263 AK027696 BAB55304 AK027701 BAG51367 AK074905 BAC11281 AK298138 BAG60416 AL137648 CAB70858 AL832267 AL832632 AL832646 CAD89982 AY089971 AAM09954 AY358577 AAQ88940 BC034713 AAH34713 BC070034 BC107425 AAI07426 BC117299 AAI17300 BC126168 AAI26169 DA106532 HQ258514 ADR83268 HQ258651 ADR83402 NM_001271581 NP_001258510 NM_018981 NP_061854 NR_073365 NR_073366 NR_073367
Function	Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. {ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:18400946, ECO:0000269|PubMed:19122239, ECO:0000269|PubMed:23769672}.
Subcellular Location	Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:23769672}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DnaJC10 (E-14) - sc-132273 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DnaJC10 (H-300) - sc-292496 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DnaJC10 (Y-14) - sc-132275 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DnaJC10 (66.7) - sc-100713 from Santa Cruz Biotechnology Prices $295.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-DNAJC10 antibody - ab197359 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 antibody - ab57376 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-DNAJC10 antibody - ab98044 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 antibody - N-terminal - ab138611 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (aa56-82, APC) - LS-C256182 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (aa56-82, AP) - LS-C256181 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (aa56-82, Biotin) - LS-C256183 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (aa56-82, FITC) - LS-C256184 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (aa56-82, Azide-free, HRP) - LS-C256185 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (aa56-82, PE) - LS-C256186 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (aa55-82) - LS-C320889 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (aa35-84) - LS-C107687 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (aa56-82) - LS-C159474 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (N-Terminus) - LS-C345472 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DNAJC10 Antibody (clone 3C4) IHC-plus™ - LS-B11250 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3C4

DNAJC10 Antibody (3C4) - H00054431-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3C4

DNAJC10 Antibody (3A8) - H00054431-M02 from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3A8

DNAJC10 Antibody (3A8) - H00054431-M02A from Novus Biologicals Prices $349.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 3A8

DNAJC10 Antibody (3C4) - H00054431-M01A from Novus Biologicals Prices $349.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 3C4

DNAJC10 Antibody - NBP1-59668 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

DNAJC10 Antibody - NBP1-83965 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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