| Gene Symbol |
RASGRP1
|
| Entrez Gene |
10125
|
| Alt Symbol |
CALDAG-GEFI, CALDAG-GEFII, RASGRP, V, hRasGRP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
|
| Other Description |
RAS guanyl nucleotide-releasing protein 1|RAS guanyl-releasing protein 1|calcium and DAG-regulated guanine nucleotide exchange factor II|guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A|ras activator RasGRP
|
| Swissprots |
Q9UNN9 O95267 Q6NX39 Q56CZ0 Q59HB1 Q6GV31 Q9UI94 Q58G75 Q7LDG6 Q5I3A8
|
| Accessions |
EAW92372 O95267 AA742351 AB208848 BAD92085 AF081195 AAC79699 AF081197 AAF21898 AF106071 AAC97349 AK295097 BAG58133 AK314091 BAG36786 AK316067 BAH14438 AY634315 AAT47482 AY858556 AAW32406 AY954625 AAX54699 AY966005 AAX76907 BC032849 BC067298 AAH67298 BC109296 AAI09297 BC109297 AAI09298 BU431038 DA993002 EU832766 ACE87777 GQ129309 ACT64443 XM_005254114 XP_005254171 XM_011521151 XP_011519453 XM_011521152 XP_011519454 XM_011521153 XP_011519455 XM_011521154 XP_011519456 XR_931740 NM_001128602 NP_001122074 NM_001306086 NP_001293015 NM_005739 NP_005730
|
| Function |
Functions as a calcium- and diacylglycerol (DAG)- regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B- lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM- dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332). {ECO:0000250|UniProtKB:Q9Z1S3, ECO:0000269|PubMed:10807788, ECO:0000269|PubMed:12782630, ECO:0000269|PubMed:12839994, ECO:0000269|PubMed:12845332, ECO:0000269|PubMed:15060167, ECO:0000269|PubMed:15184873, ECO:0000269|PubMed:15899849, ECO:000026
|
| Subcellular Location |
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860). {ECO:0000269|PubMed:10807788, ECO:0000269|PubMed:17878389, ECO:0000269|PubMed:19933860, ECO:0000269|PubMed:9789079}.
|
| Top Pathways |
T cell receptor signaling pathway, MAPK signaling pathway
|
