RASGRP1

Gene Symbol RASGRP1
Entrez Gene 10125
Alt Symbol CALDAG-GEFI, CALDAG-GEFII, RASGRP, V, hRasGRP1
Species Human
Gene Type protein-coding
Description RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Other Description RAS guanyl nucleotide-releasing protein 1|RAS guanyl-releasing protein 1|calcium and DAG-regulated guanine nucleotide exchange factor II|guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A|ras activator RasGRP
Swissprots Q9UNN9 O95267 Q6NX39 Q56CZ0 Q59HB1 Q6GV31 Q9UI94 Q58G75 Q7LDG6 Q5I3A8
Accessions EAW92372 O95267 AA742351 AB208848 BAD92085 AF081195 AAC79699 AF081197 AAF21898 AF106071 AAC97349 AK295097 BAG58133 AK314091 BAG36786 AK316067 BAH14438 AY634315 AAT47482 AY858556 AAW32406 AY954625 AAX54699 AY966005 AAX76907 BC032849 BC067298 AAH67298 BC109296 AAI09297 BC109297 AAI09298 BU431038 DA993002 EU832766 ACE87777 GQ129309 ACT64443 XM_005254114 XP_005254171 XM_011521151 XP_011519453 XM_011521152 XP_011519454 XM_011521153 XP_011519455 XM_011521154 XP_011519456 XR_931740 NM_001128602 NP_001122074 NM_001306086 NP_001293015 NM_005739 NP_005730
Function Functions as a calcium- and diacylglycerol (DAG)- regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B- lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM- dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332). {ECO:0000250|UniProtKB:Q9Z1S3, ECO:0000269|PubMed:10807788, ECO:0000269|PubMed:12782630, ECO:0000269|PubMed:12839994, ECO:0000269|PubMed:12845332, ECO:0000269|PubMed:15060167, ECO:0000269|PubMed:15184873, ECO:0000269|PubMed:15899849, ECO:000026
Subcellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860). {ECO:0000269|PubMed:10807788, ECO:0000269|PubMed:17878389, ECO:0000269|PubMed:19933860, ECO:0000269|PubMed:9789079}.
Top Pathways T cell receptor signaling pathway, MAPK signaling pathway

Human Rasgrp1 peptide - ab38777 from Abcam

Category Peptide

RASGRP1 / RASGRP Antibody Blocking Peptide - LS-E8008 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

RASGRP1 / RASGRP Antibody Blocking Peptide - LS-E23266 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

RASGRP1-Antibody-Center-Blocking-peptide - BP5856c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

BSA Conjugated Folic Acid (FA) - CPA610Ge11 from Cloud-clone

Category Protein
Source n/a

OVA Conjugated Folic Acid (FA) - CPA610Ge21 from Cloud-clone

Category Protein
Source n/a

Recombinant Human RAS guanyl-releasing protein 1(RASGRP1) - CSB-YP019362HU CSB-EP019362HU CSB-BP019362HU CSB-MP019362HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

HSA Conjugated Folic Acid (FA) - CPA610Ge41 from Cloud-clone

Category Protein
Source n/a

RASGRP1 Peptide, Human - M34GP12999H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

RASGRP1 fusion protein - Ag25736 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Rasgrp1 Recombinant Protein Antigen - NBP2-55057PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Protein V (P/V/C), Recombinant Protein - MBS1251874 from MyBioSource

Category Protein
Prices $1,135.00, $1,135.00, $1,365.00, $1,365.00, $1,810.00, $1,810.00, $2,270.00, $2,270.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

Protein V (P/V/C), Recombinant Protein - MBS1042004 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

Protein V (P/V/C), Recombinant Protein - MBS1288082 from MyBioSource

Category Protein
Prices $1,135.00, $1,135.00, $1,365.00, $1,365.00, $1,810.00, $1,810.00, $2,270.00, $2,270.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

Protein V (P/V/C), Recombinant Protein - MBS1062292 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

Protein V (P/V/C), Recombinant Protein - MBS1127891 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

RAS guanyl-releasing protein 1 (RASGRP1), Recombinant Protein - MBS1038776 from MyBioSource

Category Protein
Prices $1,630.00, $1,630.00, $1,860.00, $1,860.00, $2,755.00, $2,755.00, $3,210.00, $3,210.00, $3,210.00, $5,450.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

RASGRP1 fusion protein - Ag25725 from Proteintech Group

Category Protein
Source E. coli -derived, PGEX-4T
Species Human
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