| Gene Symbol |
KCNJ10
|
| Entrez Gene |
3766
|
| Alt Symbol |
BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, inwardly rectifying subfamily J, member 10
|
| Other Description |
ATP-dependent inwardly rectifying potassium channel Kir4.1|ATP-sensitive inward rectifier potassium channel 10|glial ATP-dependent inwardly rectifying potassium channel KIR4.1|inward rectifier K(+) channel Kir1.2|inward rectifier K+ channel KIR1.2|potassium channel, inwardly rectifying subfamily J member 10|potassium inwardly-rectifying channel, subfamily J, member 10
|
| Swissprots |
Q8N4I7 P78508 Q92808 Q5VUT9 A3KME7
|
| Accessions |
AAC50923 AAK27517 AAL89708 EAW52748 EAW52749 EAW52750 P78508 AK312383 BAG35301 BC034036 AAH34036 BC037840 BC131627 AAI31628 BE466069 BM675618 DA958759 DQ892392 ABM83318 DQ895607 ABM86533 U52155 AAB07046 U73193 AAC50924 NM_002241 NP_002232
|
| Function |
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Top Pathways |
Gastric acid secretion
|