Gene Symbol | CERS2 |
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Entrez Gene | 29956 |
Alt Symbol | L3, LASS2, SP260, TMSG1 |
Species | Human |
Gene Type | protein-coding |
Description | ceramide synthase 2 |
Other Description | LAG1 homolog, ceramide synthase 2|LAG1 longevity assurance 2|longevity assurance (LAG1, S. cerevisiae) homolog 2|tumor metastasis-suppressor gene 1 protein |
Swissprots | D3DV06 Q9HD96 Q96G23 Q9NW79 Q5SZE5 |
Accessions | CAC33275 EAW53497 EAW53498 EAW53499 EAW53500 EAW53501 EAW53502 Q96G23 AF177338 AAG17982 AF189062 AAF01058 AK001105 BAA91505 AK290989 BAF83678 AY091458 AAM12028 BC001357 AAH01357 BC010032 AAH10032 BM069521 BM764143 BQ219926 BU543940 DA019883 EU446492 ABZ92021 R94703 XM_005245107 XP_005245164 XM_011509451 XP_011507753 XM_011509452 XP_011507754 NM_022075 NP_071358 NM_181746 NP_859530 NM_013384 |
Function | Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis. |
Subcellular Location | Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in kidney, liver, brain, heart, placenta and lung. {ECO:0000269|PubMed:11543633}. |
Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |
LASS2 CRISPR/Cas9 KO Plasmid (h) - sc-403112 from Santa Cruz Biotechnology
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LASS2 HDR Plasmid (h) - sc-403112-HDR from Santa Cruz Biotechnology
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LASS2 Double Nickase Plasmid (h) - sc-403112-NIC from Santa Cruz Biotechnology
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LASS2 Double Nickase Plasmid (h2) - sc-403112-NIC-2 from Santa Cruz Biotechnology
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LASS2 CRISPR Activation Plasmid (h) - sc-403112-ACT from Santa Cruz Biotechnology
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LASS2 CRISPR Activation Plasmid (h2) - sc-403112-ACT-2 from Santa Cruz Biotechnology
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LASS2 Lentiviral Activation Particles (h) - sc-403112-LAC from Santa Cruz Biotechnology
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LASS2 Lentiviral Activation Particles (h2) - sc-403112-LAC-2 from Santa Cruz Biotechnology
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LASS2 siRNA (h) - sc-62545 from Santa Cruz Biotechnology
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LASS2 shRNA Plasmid (h) - sc-62545-SH from Santa Cruz Biotechnology
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LASS2 shRNA (h) Lentiviral Particles - sc-62545-V from Santa Cruz Biotechnology
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LASS2 RNAi - H00029956-R03 from Novus Biologicals
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LASS2 RNAi - H00029956-R02 from Novus Biologicals
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LASS2 RNAi - H00029956-R01 from Novus Biologicals
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MISSION® esiRNA - EHU078471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11561 from Sigma-Aldrich
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CERS2 siRNA (Human) - CRH9297 from Cohesion Biosciences
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CERS2 - MBS8222561 from MyBioSource
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shRNA set against Human Cers2 (NM_022075.4) - SHH262117 from Creative biogene
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LASS2 CRISPR/Cas9 KO Plasmid (h2) - sc-403112-KO-2 from Santa Cruz Biotechnology
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LASS2 HDR Plasmid (h2) - sc-403112-HDR-2 from Santa Cruz Biotechnology
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CERS2 shRNA Plasmid (Human) - CHH9297 from Cohesion Biosciences
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CERS2 miRNA 3'UTR clone - MiUTR3H-08826 from Creative biogene
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CERS2 miRNA 3'UTR clone - MiUTR3H-08827 from Creative biogene
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