| Gene Symbol |
TEX14
|
| Entrez Gene |
56155
|
| Alt Symbol |
CT113
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
testis expressed 14
|
| Other Description |
cancer/testis antigen 113|inactive serine/threonine-protein kinase TEX14|protein kinase-like protein SgK307|sugen kinase 307|testis expressed sequence 14|testis-expressed protein 14|testis-expressed sequence 14 protein
|
| Swissprots |
Q9BXT9 Q8IWB6 Q8ND97 A6NH19 Q7RTP3
|
| Accessions |
EAW94437 EAW94438 Q8IWB6 AF285601 AAK31980 AI243203 AK125896 AK128217 AK308299 AL834143 CAD38856 BC040526 AAH40526 BC045647 BG718877 BK000998 DAA01359 CB044007 CB050840 DB086121 GQ129421 ACT64555 XM_011525028 XP_011523330 XM_011525029 XP_011523331 XM_011525030 XP_011523332 XM_011525031 XP_011523333 XM_011525032 XP_011523334 XM_011525033 XP_011523335 NM_001201457 NP_001188386 NM_031272 NP_112562 NM_198393 NP_938207
|
| Function |
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Midbody {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. {ECO:0000250}.
|
| Tissue Specificity |
Detected in testis. {ECO:0000269|PubMed:11279525}.
|