| Gene Symbol | CYP2C18 |
|---|---|
| Entrez Gene | 1562 |
| Alt Symbol | CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 2, subfamily C, polypeptide 18 |
| Other Description | (S)-mephenytoin hydroxylase associated cytochrome P450|CYPIIC18|cytochrome P450 2C18|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18|cytochrome P450-6B/29C|flavoprotein-linked monooxygenase|microsomal monooxygenase|unspecific monooxygenase |
| Swissprots | P33260 Q4VAT5 Q6GRG1 Q16751 Q16703 B2R8K2 |
| Accessions | AAA02630 CAA39833 EAW50024 P33260 AK223510 BAD97230 AK308558 AK313403 BAG36199 BC069666 AAH69666 BC096257 AAH96257 BC096258 AAH96258 BC096259 BC096260 AAH96260 BJ993698 BX538127 CAD98029 HQ447473 ADQ31959 M61853 M61856 AAB59356 NM_000772 NP_000763 NM_001128925 NP_001122397 |
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Top Pathways | Chemical carcinogenesis, Retinol metabolism |