Gene Symbol | CYP2C18 |
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Entrez Gene | 1562 |
Alt Symbol | CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 2, subfamily C, polypeptide 18 |
Other Description | (S)-mephenytoin hydroxylase associated cytochrome P450|CYPIIC18|cytochrome P450 2C18|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18|cytochrome P450-6B/29C|flavoprotein-linked monooxygenase|microsomal monooxygenase|unspecific monooxygenase |
Swissprots | P33260 Q4VAT5 Q6GRG1 Q16751 Q16703 B2R8K2 |
Accessions | AAA02630 CAA39833 EAW50024 P33260 AK223510 BAD97230 AK308558 AK313403 BAG36199 BC069666 AAH69666 BC096257 AAH96257 BC096258 AAH96258 BC096259 BC096260 AAH96260 BJ993698 BX538127 CAD98029 HQ447473 ADQ31959 M61853 M61856 AAB59356 NM_000772 NP_000763 NM_001128925 NP_001122397 |
Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Top Pathways | Chemical carcinogenesis, Retinol metabolism |
CYP2C18 CRISPR/Cas9 KO Plasmid (h) - sc-409170 from Santa Cruz Biotechnology
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CYP2C18 HDR Plasmid (h) - sc-409170-HDR from Santa Cruz Biotechnology
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CYP2C18 Double Nickase Plasmid (h) - sc-409170-NIC from Santa Cruz Biotechnology
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CYP2C18 Double Nickase Plasmid (h2) - sc-409170-NIC-2 from Santa Cruz Biotechnology
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CYP2C18 CRISPR Activation Plasmid (h) - sc-409170-ACT from Santa Cruz Biotechnology
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CYP2C18 CRISPR Activation Plasmid (h2) - sc-409170-ACT-2 from Santa Cruz Biotechnology
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CYP2C18 Lentiviral Activation Particles (h) - sc-409170-LAC from Santa Cruz Biotechnology
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CYP2C18 Lentiviral Activation Particles (h2) - sc-409170-LAC-2 from Santa Cruz Biotechnology
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CYP2C18 siRNA (h) - sc-105254 from Santa Cruz Biotechnology
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CYP2C18 shRNA Plasmid (h) - sc-105254-SH from Santa Cruz Biotechnology
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CYP2C18 shRNA (h) Lentiviral Particles - sc-105254-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU066221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1803 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1803 from Sigma-Aldrich
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CYP2C18 siRNA (Human) - CRH1101 from Cohesion Biosciences
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Cytochrome P450 2C18 RNAi - H00001562-R01 from Novus Biologicals
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CYP2C18 - MBS827442 from MyBioSource
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Human CYP2C18 siRNA - orb261603 from Biorbyt
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CYP2C18 shRNA Plasmid (Human) - CHH1101 from Cohesion Biosciences
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CYP2C18 miRNA 3'UTR clone - MiUTR3H-03897 from Creative biogene
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CYP2C18 miRNA 3'UTR clone - MiUTR3H-03898 from Creative biogene
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