Gene Symbol | ORC1 |
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Entrez Gene | 4998 |
Alt Symbol | HSORC1, ORC1L, PARC1 |
Species | Human |
Gene Type | protein-coding |
Description | origin recognition complex, subunit 1 |
Other Description | origin recognition complex subunit 1|origin recognition complex, subunit 1 homolog|replication control protein 1 |
Swissprots | Q5T0F5 D3DQ34 Q13415 Q13471 |
Accessions | EAX06783 EAX06784 Q13415 AK291909 BAF84598 AK303420 BAH13956 BC011539 AAH11539 BP280383 DB156841 U40152 AAC50325 U43416 AAA86260 XM_011541527 XP_011539829 NM_001190818 NP_001177747 NM_001190819 NP_001177748 NM_004153 NP_004144 |
Function | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
Subcellular Location | Nucleus. |
Top Pathways | Cell cycle |
ORC1 CRISPR/Cas9 KO Plasmid (h) - sc-418358 from Santa Cruz Biotechnology
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ORC1 HDR Plasmid (h) - sc-418358-HDR from Santa Cruz Biotechnology
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ORC1 Double Nickase Plasmid (h) - sc-418358-NIC from Santa Cruz Biotechnology
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ORC1 Double Nickase Plasmid (h2) - sc-418358-NIC-2 from Santa Cruz Biotechnology
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ORC1 CRISPR Activation Plasmid (h) - sc-418358-ACT from Santa Cruz Biotechnology
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ORC1 CRISPR Activation Plasmid (h2) - sc-418358-ACT-2 from Santa Cruz Biotechnology
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ORC1 Lentiviral Activation Particles (h) - sc-418358-LAC from Santa Cruz Biotechnology
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ORC1 Lentiviral Activation Particles (h2) - sc-418358-LAC-2 from Santa Cruz Biotechnology
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ORC1 siRNA (h) - sc-38151 from Santa Cruz Biotechnology
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ORC1 shRNA Plasmid (h) - sc-38151-SH from Santa Cruz Biotechnology
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ORC1 shRNA (h) Lentiviral Particles - sc-38151-V from Santa Cruz Biotechnology
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ORC1 RNAi - H00004998-R02 from Novus Biologicals
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MISSION® esiRNA - EHU003051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16143 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16143 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03405 from Sigma-Aldrich
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ORC1 siRNA (Human) - CRH3316 from Cohesion Biosciences
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shRNA set against Human ORC1 (NM_004153.3) - SHH368396 from Creative biogene
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ORC1 shRNA Plasmid (Human) - CHH3316 from Cohesion Biosciences
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ORC1 miRNA 3'UTR clone - MiUTR4H-TG06325 from Creative biogene
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