LMNA

Gene Symbol LMNA
Entrez Gene 4000
Alt Symbol CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Species Human
Gene Type protein-coding
Description lamin A/C
Other Description 70 kDa lamin|lamin|lamin A/C-like 1|prelamin-A/C|renal carcinoma antigen NY-REN-32
Swissprots Q6UYC3 D6RAQ3 Q969I8 Q5I6Y6 Q5TCJ3 P02545 P02546 Q5TCJ2 B4DI32 D3DVB0 E7EUI9 Q5I6Y4 Q96JA2
Accessions AHI07399 AHI07400 AHI07401 AHI07402 AHI07403 AHI07404 AHI07405 AHI07406 AHI07407 AHI07408 AHI07409 AHI07410 AHI07411 AHI07412 AHL67294 EAW52996 EAW52997 EAW52998 EAW52999 EAW53000 P02545 AA558657 AF381029 AAK59326 AI872233 AK026584 AK056143 AK056191 AK057997 AK097801 AK098128 AK122732 AK130179 AK294217 BAG57524 AK295390 BAG58344 AK309539 AY357727 AAR29466 AY528714 ABB04050 AY847595 AAW32538 AY847596 AAW32539 AY847597 AAW32540 BC000511 AAH00511 BC003162 AAH03162 BC014507 AAH14507 BC018863 BC033088 AAH33088 BG822820 BU685425 BU732343 CB854404 DA421696 DA551594 DB270595 DC400775 EU831758 ACE87276 EU831836 ACE86595 EU832167 ACE87517 EU832261 ACE86831 HY027676 M13451 AAA36164 M13452 AAA36160 X03444 CAA27173 X03445 CAA27174 XM_011509533 XP_011507835 XM_011509534 XP_011507836 XR_921781 NM_001257374 NP_001244303 NM_001282624 NP_001269553 NM_001282625 NP_001269554 NM_001282626 NP_001269555 NM_005572 NP_005563 NM_170707 NP_733821 NM_170708 NP_733822
Function Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.
Subcellular Location Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin- A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.
Tissue Specificity In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. {ECO:0000269|PubMed:20458013}.
Top Pathways Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

Lamin A/C (4C11) Mouse mAb (Alexa Fluor ® 488 Conjugate) - 8617 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone 4C11
Confocal immunofluorescent analysis of normal rat brain using Lamin A/C (4C11) Mouse mAb (Alexa Fluor ® 488 Conjugate) (green). Actin filaments were labeled with DY-554 phalloidin (red). Blue pseudocolor = DRAQ5 ® (fluorescent DNA dye).

Cleaved Lamin A (Small Subunit) (30H5) Mouse mAb - 2036 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 30H5
Western blot analysis of extracts from HeLa, NIH/3T3, and C6 cells, untreated or staurosporine-treated (1 µM), and Jurkat cells, untreated or etoposide-treated (25 µM), using Cleaved Lamin A (Small Subunit) (30H5) Mouse mAb.

Cleaved Lamin A (Small Subunit) Antibody - 2035 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3 or C6 cells, untreated or staurosporine-treated (1 µM), using Cleaved Lamin A (Small Subunit) Antibody.

Phospho-Lamin A/C (Ser22) (D2B2E) XP ® Rabbit mAb - 13448 from Cell Signaling Technology

Prices $119.00, $318.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2B2E
Western blot analysis of extracts from HeLa, NIH/3T3, and C6 cells, treated with either hydroxyurea (4 mM, 20 hr; +) to induce G1/S phase or Paclitaxel #9807 (100 nM, 20 hr; +) to induce G2/M phase, using Phospho-Lamin A/C (Ser22) (D2B2E) XP ® Rabbit mAb (upper) and Lamin A/C Antibody #2032 (lower).

Phospho-Lamin A/C (Ser22) Antibody - 2026 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and NIH/3T3 cells, hydroxyurea-treated (4 mM, 20 hours) to induce G1/S phase or paclitaxel-treated (100 nM, 20 hours) or nocodazole-treated (100 ng/ml, 20 hours) to induce G2/M phase, using Phospho-Lamin A/C (Ser22) Antibody (upper) or Lamin A/C Antibody #2032 (lower) as a loading control.

Cleaved Lamin A (Asp230) Antibody - 2031 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or staurosporine-treated (1 µM), using Cleaved Lamin A (Asp230) Antibody (upper) or Lamin A Antibody #2032 (lower).

Lamin A/C (4C11) Mouse mAb - 4777 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (20 western blots)
Host Mouse
Clonality Monoclonal
Clone 4C11
Western blot analysis of extracts from various cell lines using Lamin A/C (4C11) Mouse mAb.

Lamin A/C Antibody - 2032 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or staurosporine-treated (1 µM), using Lamin A/C Antibody.

Lamin A (C-20) - sc-6214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Lamin A (C-20): sc-6214. Western blot analysis of Lamin A expression in untreated (A) and staurosporine-induced (B) HeLa whole cell lysates.

Lamin A (H-102) - sc-20680 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Lamin A (H-102): sc-20680. Immunofluorescence staining of normal mouse kidney frozen section showing nuclear envelope staining.

Lamin A (4A58) - sc-71481 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Lamin A (4A58): sc-71481. Western blot analysis of Lamin A expression in Hs68 whole cell lysate.

Lamin A (133A2) - sc-56137 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal

Lamin A/C (A-5) - sc-398927 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lamin A/C (A-5): sc-398927. Western blot analysis of Lamin A expression in non-transfected 293T: sc-117752 (A), human Lamin A transfected 293T: sc-177452 (B) and HeLa (C) whole cell lysates.

Lamin A/C (N-18) - sc-6215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Lamin A/C (N-18): sc-6215. Western blot analysis of Lamin A/C expression in FSH 173 (A) and Hs68 (B) whole cell lysates.

Lamin A/C (E-1) - sc-376248 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lamin A/C (E-1): sc-376248. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear envelope localization.

Lamin A/C (H-110) - sc-20681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ATF-2 siRNA (h): sc-29205. Western blot analysis of ATF-2 expression in non-transfected control (A) and ATF-2 siRNA transfected (B) HeLa cells. Blot probed with ATF-2 (N-96): sc-6233. Lamin A/C (H-110): sc-20681 used as specificity and loading control.

Lamin A/C (636) - sc-7292 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lamin A/C (636) Alexa Fluor 647: sc-7292 AF647. Intracellular FCM analysis of fixed and permeabilized HeLa cells. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>: sc-24638.

Lamin A/C (346) - sc-7293 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lamin A/C (346): sc-7293. Western blot analysis of Lamin A/C expression in CCD-1064Sk (A) and FHs 173We (B) whole cell lysates.

Lamin A/C (JoL3) - sc-56140 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal
Lamin A/C (JoL3): sc-56140. Western blot analysis of Lamin A/C expression in HeLa (A) and AP treated Hs68 (B) whole cell lysates.

Lamin A/C (JoL5) - sc-56141 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal
Lamin A/C (JoL5): sc-56141. Western blot analysis of Lamin A/C expression in HeLa whole cell lysate.

cleaved Lamin A/C (h230) - sc-25105 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cleaved Lamin A/C (h230): sc-25105. Western blot analysis of cleaved Lamin A/C expression in mouse heart tissue extract.

Progerin (13A4D4) - sc-81611 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] - ab176549 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5H8-B4
Lane 1 : Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] (ab176549) at 1/50 dilutionLane 2 : Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] (ab176549) at 1/200 dilutionLane 3 : Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] (ab176549) at 1/1000 dilutionLane 4 : Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] (ab176549) at 1/2000 dilutionLane 5 : Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] (ab176549) at 1/4000 dilutionLane 6 : Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] (ab176549) at 1/8000 dilutionLane 7 : Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] (ab176549) at 1/16000 dilutionLane 8 : Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] (ab176549) at 1/32000 dilutionLane 1 : HeLa cell lysateLane 2 : HeLa cell lysateLane 3 : HeLa cell lysateLane 4 : HeLa cell lysateLane 5 : HeLa cell lysateLane 6 : HeLa cell lysateLane 7 : HeLa cell lysateLane 8 : HeLa cell lysateSecondaryAnti-mouse IgG (whole molecule)-AP conjugate at 1/2000 dilution

Anti-Lamin A + C (mutated R482 W) antibody [5H8-B4] (HRP) - ab187942 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5H8-B4

Anti-Lamin A + C (phospho S392) antibody - ab58528 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Lamin A + C (phospho S392) antibody (ab58528) at 1/500 dilutionLane 1 : Extracts from Hela cellsLane 2 : Extracts from Hela cells with immunizing peptide
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