HSD17B12

Gene Symbol	HSD17B12
Entrez Gene	51144
Alt Symbol	KAR, SDR12C1
Species	Human
Gene Type	protein-coding
Description	hydroxysteroid (17-beta) dehydrogenase 12
Other Description	17-beta-HSD 12|17-beta-hydroxysteroid dehydrogenase 12|17beta-HSD type 12|3-ketoacyl-CoA reductase|estradiol 17-beta-dehydrogenase 12|short chain dehydrogenase/reductase family 12C member 1|short chain dehydrogenase/reductase family 12C, member 1|steroid dehydrogenase homolog|very-long-chain 3-oxoacyl-CoA reductase
Swissprots	Q96EA9 A8K9B0 D3DR23 Q9Y6G8 Q96JU2 Q53GQ0
Accessions	CAF86901 CAF86962 EAW68080 EAW68081 EAW68082 EAW68083 EAW68084 EAW68085 EAW68086 EAW68087 EAW68088 EAW68089 Q53GQ0 AF078850 AAD44482 AK027882 AK074952 BAG52039 AK075011 BAG52052 AK075216 BAG52086 AK092938 AK222881 BAD96601 AK292625 BAF85314 AK301663 BAG63138 BC012043 AAH12043 BC012536 AAH12536 BP359822 BX537496 EU176708 ABW03509 XM_011520156 XP_011518458 NM_016142 NP_057226
Function	Catalyzes the second of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3- ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:12482854}; Multi-pass membrane protein {ECO:0000269|PubMed:12482854}.
Tissue Specificity	Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16113833, ECO:0000269|PubMed:16166196}.
Top Pathways	Steroid hormone biosynthesis, Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

17β-HSD12 (D-13) - sc-161281 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

17β-HSD12 (T-18) - sc-161282 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-HSD17B12 antibody - ab103107 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B12 antibody - ab112011 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 antibody - ab88133 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-HSD17B12 antibody - ab68333 from Abcam Prices $370.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-HSD17B12 antibody - C-terminal - ab140398 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa126-155, APC) - LS-C258921 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa126-155, AP) - LS-C258920 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa126-155, Biotin) - LS-C258922 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa126-155, FITC) - LS-C258923 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa126-155, Azide-free, HRP) - LS-C258924 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa126-155, PE) - LS-C258925 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa11-291, Biotin) - LS-C298659 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa1-312, Biotin) - LS-C299337 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa11-291, FITC) - LS-C302744 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa1-312, FITC) - LS-C304394 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody - LS-C308317 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-HSD17B12 Antibody (aa27-181) - LS-C178562 from LifeSpan Bioscience Prices $255.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa203-272) - LS-C308323 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-HSD17B12 Antibody (aa133-163) - LS-C322103 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa11-291) - LS-C292547 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa1-312) - LS-C292549 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (C-Terminus) - LS-C345806 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B12 Antibody (aa126-155) - LS-C165033 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

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