HSD17B12

Gene Symbol HSD17B12
Entrez Gene 51144
Alt Symbol KAR, SDR12C1
Species Human
Gene Type protein-coding
Description hydroxysteroid (17-beta) dehydrogenase 12
Other Description 17-beta-HSD 12|17-beta-hydroxysteroid dehydrogenase 12|17beta-HSD type 12|3-ketoacyl-CoA reductase|estradiol 17-beta-dehydrogenase 12|short chain dehydrogenase/reductase family 12C member 1|short chain dehydrogenase/reductase family 12C, member 1|steroid dehydrogenase homolog|very-long-chain 3-oxoacyl-CoA reductase
Swissprots Q96EA9 A8K9B0 D3DR23 Q9Y6G8 Q96JU2 Q53GQ0
Accessions CAF86901 CAF86962 EAW68080 EAW68081 EAW68082 EAW68083 EAW68084 EAW68085 EAW68086 EAW68087 EAW68088 EAW68089 Q53GQ0 AF078850 AAD44482 AK027882 AK074952 BAG52039 AK075011 BAG52052 AK075216 BAG52086 AK092938 AK222881 BAD96601 AK292625 BAF85314 AK301663 BAG63138 BC012043 AAH12043 BC012536 AAH12536 BP359822 BX537496 EU176708 ABW03509 XM_011520156 XP_011518458 NM_016142 NP_057226
Function Catalyzes the second of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3- ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12482854}; Multi-pass membrane protein {ECO:0000269|PubMed:12482854}.
Tissue Specificity Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16113833, ECO:0000269|PubMed:16166196}.
Top Pathways Steroid hormone biosynthesis, Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

Human HSD17B12 full length protein - ab132771 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab132771 stained with Coomassie Blue.

Human HSD17B12 protein fragment - ab127062 from Abcam

Category Protein
Source E. coli
Species Human

HSD17B12 Antibody Blocking Peptide - LS-E10081 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human HSD17B12 Protein - H00051144-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human HSD17B12 Protein - H00051144-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

HSD17B12-Antibody-Center-Blocking-Peptide - BP9351c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

17-beta-HSD12 / HSD17B12 - H00051144-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

17-beta-HSD12 / HSD17B12 - H00051144-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

17-beta-HSD12 / HSD17B12 - H00051144-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

17-beta-HSD12 / HSD17B12 - H00051144-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Recombinant Human HSD17B12, GST-tagged - HSD17B12-46H from Creative Biomart

Category Protein
Source Wheat germ
Species Human

Recombinant Human HSD17B12, GST-tagged - HSD17B12-47H from Creative Biomart

Category Protein
Source Wheat germ
Species Human

Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) - RPF182Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) - RPF182Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) - RPF182Ra01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Rat

Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) - RPF182Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

3-ketoacyl-CoA reductase (ACLA_070510), Recombinant Protein - MBS1131927 from MyBioSource

Category Protein
Prices $1,705.00, $2,165.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Aspergillus

3-ketoacyl-CoA reductase (AFUB_027290), Recombinant Protein - MBS1092636 from MyBioSource

Category Protein
Prices $1,705.00, $2,165.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Neosartorya

3-ketoacyl-CoA reductase (An02g03570), Recombinant Protein - MBS1192842 from MyBioSource

Category Protein
Prices $1,710.00, $2,165.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Aspergillus

3-ketoacyl-CoA reductase (BC1G_11561), Recombinant Protein - MBS1081566 from MyBioSource

Category Protein
Prices $1,675.00, $2,135.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

3-ketoacyl-CoA reductase (CC1G_02019), Recombinant Protein - MBS1000854 from MyBioSource

Category Protein
Prices $1,695.00, $2,150.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

3-ketoacyl-CoA reductase (CNBH0660), Recombinant Protein - MBS1137935 from MyBioSource

Category Protein
Prices $1,745.00, $2,200.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

3-ketoacyl-CoA reductase (CNI00690), Recombinant Protein - MBS1197101 from MyBioSource

Category Protein
Prices $1,745.00, $2,200.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

3-ketoacyl-CoA reductase (HCAG_07127), Recombinant Protein - MBS1111563 from MyBioSource

Category Protein
Prices $1,695.00, $2,150.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Ajellomyces

3-ketoacyl-CoA reductase (Kpol_513p6), Recombinant Protein - MBS1117983 from MyBioSource

Category Protein
Prices $1,710.00, $2,170.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
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